High-fat diet impairs satiation signaling in obese-prone

High-fat diet impairs satiation signaling in obese-prone
Feeding obese-prone rats a high-fat diet leads to impaired satiation signaling through glucagon-like peptide-1, a gastrointestinal hormone that suppresses food intake and helps regulate energy balance, according to a study published online Feb. 19 in Diabetes.

(HealthDay)—Feeding obese-prone rats a high-fat diet leads to impaired satiation signaling through glucagon-like peptide-1 (GLP-1), a gastrointestinal hormone that suppresses food intake and helps regulate energy balance, according to a study published online Feb. 19 in Diabetes.

Frank A. Duca, Ph.D., from the Institut National de la Recherche Agronomique in Jouy-en-Josas, France, and colleagues compared in obese-prone and obese-resistant rats fed either normally or a high-energy/high-fat diet, after treatment with the GLP-1 receptor (GLP-1R) agonist exendin-4 or vehicle.

The researchers found that, while exendin-4 suppressed food intake in both types of rats when fed a normal diet, exendin-4 suppressed food intake significantly less in obese-prone rats than obese-resistant rats when fed a high-energy/high-fat diet. Obese-prone rats on a high-energy/high-fat diet had lower GLP-1R expression in the vagal nodose ganglia, less GLP-1 in serum and the , and fewer L-cells in the distal ileum.

"These results demonstrate that high-energy/high-fat-feeding coupled with obese-prone phenotype results in reduced endogenous GLP-1 and GLP-1R activation, indicating that impaired GLP-1 signaling during obesity may exacerbate hyperphagia and weight gain," Duca and colleagues conclude.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Natural fibre may take extra pounds away

Jan 31, 2007

It sounds almost too good to be true, but Dr. Raylene Reimer, a researcher at the University of Calgary, Faculty of Kinesiology, believes she may have found an important weapon in the war against obesity.

Importance of diabetes genetic variants unclear

Apr 04, 2012

(HealthDay) -- Genetic variants associated with type 2 diabetes that affect glucagon-like peptide 1 (GLP-1) are not associated with GLP-1 levels or GLP-1-induced insulin secretion in healthy individuals, according ...

Recommended for you

Blood glucose levels set for achieving HbA1c targets

Apr 11, 2014

(HealthDay)—The average self-monitored blood glucose (SMBG) concentrations needed at premeal, postmeal, and bedtime have been established to achieve a range of hemoglobin A1c (HbA1c) targets, according ...

Women with diabetes less likely to have a mammogram

Apr 11, 2014

Women with diabetes are 14 per cent less likely to be screened for breast cancer compared to women without diabetes, according to a study by researchers at the Institute for Clinical Evaluative Sciences (ICES) and Women's ...

Nonalcoholic fatty liver disease linked to CKD in T1DM

Apr 09, 2014

(HealthDay)—For patients with type 1 diabetes, nonalcoholic fatty liver disease (NAFLD) is independently associated with the risk of incident chronic kidney disease (CKD), according to a study published ...

User comments