High-fat diet impairs satiation signaling in obese-prone

High-fat diet impairs satiation signaling in obese-prone
Feeding obese-prone rats a high-fat diet leads to impaired satiation signaling through glucagon-like peptide-1, a gastrointestinal hormone that suppresses food intake and helps regulate energy balance, according to a study published online Feb. 19 in Diabetes.

(HealthDay)—Feeding obese-prone rats a high-fat diet leads to impaired satiation signaling through glucagon-like peptide-1 (GLP-1), a gastrointestinal hormone that suppresses food intake and helps regulate energy balance, according to a study published online Feb. 19 in Diabetes.

Frank A. Duca, Ph.D., from the Institut National de la Recherche Agronomique in Jouy-en-Josas, France, and colleagues compared in obese-prone and obese-resistant rats fed either normally or a high-energy/high-fat diet, after treatment with the GLP-1 receptor (GLP-1R) agonist exendin-4 or vehicle.

The researchers found that, while exendin-4 suppressed food intake in both types of rats when fed a normal diet, exendin-4 suppressed food intake significantly less in obese-prone rats than obese-resistant rats when fed a high-energy/high-fat diet. Obese-prone rats on a high-energy/high-fat diet had lower GLP-1R expression in the vagal nodose ganglia, less GLP-1 in serum and the , and fewer L-cells in the distal ileum.

"These results demonstrate that high-energy/high-fat-feeding coupled with obese-prone phenotype results in reduced endogenous GLP-1 and GLP-1R activation, indicating that impaired GLP-1 signaling during obesity may exacerbate hyperphagia and weight gain," Duca and colleagues conclude.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Natural fibre may take extra pounds away

Jan 31, 2007

It sounds almost too good to be true, but Dr. Raylene Reimer, a researcher at the University of Calgary, Faculty of Kinesiology, believes she may have found an important weapon in the war against obesity.

Importance of diabetes genetic variants unclear

Apr 04, 2012

(HealthDay) -- Genetic variants associated with type 2 diabetes that affect glucagon-like peptide 1 (GLP-1) are not associated with GLP-1 levels or GLP-1-induced insulin secretion in healthy individuals, according ...

Recommended for you

Economic burden of prediabetes up 74 percent over five years

Nov 20, 2014

The economic burden of diabetes in America continues to climb, exceeding more than $322 billion in excess medical costs and lost productivity in 2012, or more than $1,000 for every American, according to a study being published ...

Gynoid fat resists metabolic risks of obesity

Nov 19, 2014

(HealthDay)—The differences in the developmental profiles of upper-body and lower-body fat depots may explain their opposing associations with obesity-related metabolic disease, according to research published ...

Treating diabetes one meal at a time

Nov 19, 2014

Recent estimates project that as many as one in three American adults will have diabetes in 2050. The American Diabetes Association observes November as American Diabetes Month, and this year's theme is America ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.