High hsCRP may up risk of macular edema in T1DM

High hsCRP may up risk of macular edema in T1DM
For patients with type 1 diabetes mellitus, elevated levels of high-sensitivity C-reactive protein are associated with an increased risk of clinically significant macular edema and with the development of retinal hard exudates, according to a study published online Feb. 7 in JAMA Ophthalmology.

(HealthDay)—For patients with type 1 diabetes mellitus, elevated levels of high-sensitivity C-reactive protein (hsCRP) are associated with an increased risk of clinically significant macular edema (CSME) and with the development of retinal hard exudates, according to a study published online Feb. 7 in JAMA Ophthalmology.

In a large multicenter randomized trial (Diabetes Control and Complications Trial [DCCT]), Rajeev H. Muni, M.D., from St. Michael's Hospital and the Hospital for Sick Children in Toronto, and colleagues examined whether baseline hsCRP and intercellular adhesion molecule 1 (ICAM-1) levels predict the development and progression of , CSME, and retinal hard exudates. The study population included 1,441 subjects with .

After adjustment for randomized treatment assignment and additional variables, the researchers identified an association between hsCRP and the risk of CSME (relative risk, 1.83 for highest versus lowest quintile; 95 percent confidence interval [CI], 0.94 to 3.55) and for the development of retinal hard exudates (relative risk, 1.78 for highest versus lowest quintile; 95 percent CI, 0.98 to 3.25). For ICAM-1, the relative risk of developing retinal hard exudates was 1.50 for the highest versus lowest quintile (95 percent CI, 0.84 to 2.68).

"After adjusting for known risk factors, increasing quintiles of baseline level may be associated with higher risk of incident CSME and macular hard exudate in the DCCT cohort," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Microaneurysm turnover IDs macular edema development

Jan 08, 2013

(HealthDay)—Microaneurysm (MA) turnover independently predicts the development of clinically significant macular edema (CSME) in patients with non-proliferative diabetic retinopathy (NPDR), according to ...

Findings support link between hsCRP, macular degeneration

Feb 08, 2013

(HealthDay)—Pooled results from five cohorts confirm that high levels of high-sensitivity C-reactive protein (hsCRP) correlate with increased future risk of age-related macular degeneration (AMD), according ...

Clopidogrel after MI less effective in diabetes patients

Sep 05, 2012

(HealthDay)—Clopidogrel therapy following a heart attack does less to reduce the risk of death in patients with diabetes than in those without diabetes, according to a study published in the Sept. 5 issue ...

Low HDL cholesterol ups risk of diabetic nephropathy

Aug 22, 2012

(HealthDay) -- High-density lipoprotein cholesterol (HDL-C) is an independent risk factor for the development of diabetic nephropathy, but not retinopathy, in patients with type 2 diabetes, according to research ...

Recommended for you

Simple test could detect serious eye condition early

Aug 28, 2014

A simple colour test that could detect the early onset of a condition which accounts for over half of visual impairment certifications in the UK is being researched by scientists at Aston University.

Yellow pigment in eye may aid vision through haze

Aug 25, 2014

Individuals with greater amounts of yellow pigment in the eye may be better able to see distant objects in hazy conditions, suggests a study in the September issue of Optometry and Vision Science, official journal of the A ...

New DNA test for diagnosing diseases linked to childhood blindness

Aug 21, 2014

Researchers in the United Kingdom have demonstrated that advanced DNA testing for congenital cataracts can quickly and accurately diagnose a number of rare diseases marked by childhood blindness, according to a study published online today in Ophthalmology, the journal of the American Academy o ...

User comments