Nanotechnology against pollen allergy
Scientists at the Charité – Universitätsmedizin Berlin have now been able to identify the grass pollen molecule, against which the allergic response of hay fever in children is initiated. In addition, it was shown that the first individual antibodies generated in children against individual pollen molecules can be identified even before the initial symptoms of a pollen allergy are developed. The findings of this long-term study have appeared in the Journal of Allergy and Clinical Immunology.
In its study, the Molecular Allergology working group headed by Adj. Professor Dr. Paolo Matricardi of the Department of Pediatrics, Division of Pneumonology and Immunology at the Campus Virchow-Klinikum, investigated the data and blood samples taken from 820 children. These children come from five cities in Germany and had been taking part in this multicenter allergy study since their birth in 1990. As part of a sub-project investigating the development of the allergic immune response in childhood, which was funded by the Deutsche Forschungsgemeinschaft (German Research Foundation), the working group was for the first time also able to examine the data using nanotechnological methods at a molecular level. Hitherto in current allergy diagnostics, antibodies against a natural grass pollen extract (a mixture of several allergenic modules) are detected. In this study, a so-called allergen chip was used, which enables antibodies against individual, microscopically small pollen molecules to be made visible and identified.
The research findings of the study show that the special proteins used by the body's immune system to repel invading pathogens, the so-called IgE antibodies, can be developed years before the first symptoms occur. These antibodies can be identified in children even at pre-school age. They represent key biomarkers that indicate whether a child will suffer from a grass pollen allergy. In addition, a single pollen molecule was identified, the so-called Phl p 1, which in most cases stands at the head of the reaction chain: although the children affected initially only develop a few IgE antibodies to a specific type of pollen, they subsequently create other IgE antibodies to other pollen molecules as well. The immune system responds to an increasing number of different allergens, often before allergic symptoms are recognisable. Methods of treatment, such as hypo- or desensitisation, do not invariably lead to success. One reason for this might be that the therapy does not start until the children affected are already suffering from the allergy, and the body has already created antibodies against a range of different allergen molecules.
"The detection of lgE antibodies at an early stage could enhance the prospects of a successful therapeutic and even preventative intervention", according to a confident Laura Hatzler, the first author of the study. "The investigation of allergen-specific, immunological treatments at early stages of the disease process in childhood represents the next step in our research."
More information: Hatzler, Laura et al. 2012. Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever. Journal of Allergy and Clinical Immunology, Volume 130, 827-1016. doi: 10.1016/j.jaci.2012.05.053
Journal reference: Journal of Allergy and Clinical Immunology
Provided by Charité - Universitätsmedizin Berlin
- 'Apple allergy': Symptoms could be significantly reduced with apple-allergen treatment Oct 19, 2012 | not rated yet | 0
- Probiotic drinks help against allergies Jun 16, 2011 | not rated yet | 0
- Some pollens are much more aggressive than others May 21, 2012 | not rated yet | 0
- Get ready for spring - hay fever worse in spring than summer Dec 21, 2011 | not rated yet | 0
- Munich researchers discover key allergy gene Aug 22, 2008 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Force Between Two Concentric Solenoids
2 hours ago Imagine a finite length solenoid with outer radius R1 and inner radius R2. This solenoid has a time-varying current going though it. This solenoid is...
Synchrotron, question about insertion devices and electron velocity
2 hours ago When an electron enters an insertion device (wiggler and undulator) from the storage ring in a synchrotron the tangential velocity is equal to the...
Equating differentials => equating coefficients
4 hours ago Hi all, In thermodynamics one often has equations like A dx + B dy = ∂f/∂x dx + ∂f/∂y dy From which follows A = ∂f/∂x B = ∂f/∂y
The idea behind a reverse shock
10 hours ago So in a supernova explosion for example (5th slide) http://www.astro.princeton.edu/~burrows/classes/541/blastwavesChisari.pdf Ambient medium is...
Guass's Law for a charge distribution
10 hours ago First, this is not a homework question, just something I've been confused about for some time. I understand how to use Guass's law in many ways but...
11 hours ago Hello :) i'm new to this forum, so excuse me for my straightforwardness ;) I'm working on my bachelor work and i can't find a solution. I'm writing...
- More from Physics Forums - Classical Physics
More news stories
Kate O'Reilly's spring allergy survival kit includes the usual stuff - nasal sprays, allergy pills and a box of tissues. This season, she's added a new weapon to her line of defense: an app on her smartphone.
Immunology May 24, 2013 | not rated yet | 0
Biological processes are generally based on events at the molecular and cellular level. To understand what happens in the course of infections, diseases or normal bodily functions, scientists would need to ...
Immunology May 24, 2013 | 5 / 5 (5) | 0 |
(Medical Xpress)—Scientists at Emory Vaccine Center have shown that an immune regulatory molecule called IL-21 is needed for long-lasting antibody responses in mice against viral infections.
Immunology May 23, 2013 | 5 / 5 (2) | 0 |
Human breastmilk responds quickly to protect the child when there is an infection in mothers or babies, according to new international research led by The University of Western Australia.
Immunology May 23, 2013 | 5 / 5 (1) | 0
Coenzyme Q10 decreases all cause mortality by half, according to the results of a multicentre randomised double blind trial presented today at Heart Failure 2013 congress. It is the first drug to improve heart failure mortality ...
16 hours ago | 5 / 5 (2) | 5
(HealthDay)—Animals make great companions for senior citizens, but elderly people who always drive with a pet in the car are far more likely to crash than those who never drive with a pet, researchers have ...
8 hours ago | not rated yet | 1
Heart failure accelerates the aging process and brings on early andropausal syndrome (AS), according to research presented today at the Heart Failure Congress 2013. AS, also referred to as male 'menopause', was four times ...
16 hours ago | not rated yet | 1
Mortality and length of stay are highest in heart failure patients admitted in January, on Friday, and overnight, according to research presented today at the Heart Failure Congress 2013. The analysis of nearly 1 million ...
16 hours ago | not rated yet | 0
(AP)—Department of Justice lawyers have again asked a federal appeals court in New York to delay lifting age restrictions and prescription requirements on an emergency contraceptive popularly known as the morning-after ...
16 hours ago | not rated yet | 0