Better outcome for frozen embryo replacement vs IVF

In a study to be presented on February 14 at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting, in San Francisco, California, researchers will present findings showing perinatal outcomes of frozen/thawed embryo replacement (FER) have better outcomes compared to fresh in vitro fertilization (IVF), but worse outcomes compared to the non-IVF general population.

The study collected data from all IVF treatments in Denmark, Norway and Sweden from 1984 – 2007, then cross-linked with the Nordic Medical Birth Registries. Babies born after FER (6,653) were compared to those born after fresh IVF (42,287) and the general population (288,868). Researchers looked for eight different outcomes: low birth weight, very , preterm birth, very preterm birth, small for , macrosomia (excessive birth weight), large for gestational age, and .

"FER is used increasingly in IVF programs to avoid the risks associated with ," said Ulla-Britt Wennerholm, of Sahlgrenska University Hospital in Göteberg, Sweden. "We sought to analyze the outcomes compared to spontaneous conceptions and fresh IVF."

Dr. Wennerholm and her associates found children born after FER had higher rates of PTB, very PTB, LBW, very LBW, LGA, and macrosomia compared to spontaneous conceptions. However, when compared to fresh IVF births, children born after FER fared better, having lower rates of PTB, LBW, and SGA. But they also found children born after FER to have higher rates of LGA and macrosomia than those born from fresh IVF.

Researchers concluded outcomes for FER to be better compared to fresh IVF, but worse compared to the general population. However, they believe the higher rates of LGA and macrosomia compared to fresh IVF will require further attention.

Provided by Society for Maternal-Fetal Medicine

not rated yet
add to favorites email to friend print save as pdf

Related Stories

Frozen embryo transfer leads to larger and heavier babies

Jul 05, 2011

Two studies from France and Denmark have shown that children born after frozen embryo transfer are larger and heavier. The risk for a baby to be too heavy for its gestational age at birth is increased 1.6 fold compared to ...

Factors affecting obstetric outcomes of IVF singletons

Jul 05, 2011

Further evidence of how maternal characteristics can influence the development of children born after in vitro fertilization was presented to the annual conference of the European Society of Human Fertilization and Embryology ...

Recommended for you

UK proposes rules for embryos made from 3 people

Dec 17, 2014

(AP)—New rules proposed in Britain would make it the first country to allow embryos to be made from the DNA of three people in order to prevent mothers from passing on potentially fatal genetic diseases to their babies.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.