Pertactin-negative Bordetella pertussis identified in U.S.

Pertactin-negative <i>Bordetella pertussis</i> identified in U.S.
Pertactin-negative variants of Bordetella pertussis have been identified in the United States; and children who receive diphtheria-tetanus-whole-cell pertussis priming have lower reported rates of pertussis, according to correspondence published in the Feb. 7 issue of the New England Journal of Medicine.

(HealthDay)—Pertactin-negative variants of Bordetella pertussis have been identified in the United States; and children who receive diphtheria-tetanus-whole-cell pertussis (DTwP) priming have lower reported rates of pertussis, according to correspondence published in the Feb. 7 issue of the New England Journal of Medicine.

Noting an increase in the numbers of cases of pertussis in several countries, including the United States, despite increased vaccination, Anne Marie Queenan, Ph.D., from Janssen Research and Development in Raritan, N.J., and colleagues examined the contribution of pertactin-negative variants of B. pertussis. The researchers found that 11 of 12 isolates of B. pertussis cultured from specimens from children hospitalized in Philadelphia were negative for pertactin.

Juventila Liko, M.D., M.P.H., from the Oregon Health Authority in Portland, and colleagues examined the effectiveness of first-dose DTwP priming in children fully immunized with --acellular pertussis (DTaP) beyond their first year or life and in those who received a DTaP booster. Using data from April 1997 through July 2012, 484 cases of pertussis were reported, 402 of which were matched to the Oregon immunization information system ALERT IIS. The researchers found that the reported rates of pertussis were lower among children who had started the vaccination process with DTwP. Higher rates of reported pertussis were seen for children who underwent priming with acellular versus whole-cell pertussis.

"The balance between vaccine side effects and effectiveness needs to be considered in developing and implementing recommendations on pertussis vaccination, particularly in light of recent outbreaks of pertussis," Liko and colleagues write.

More information: Full Text - Queenan
Full Text - Liko

add to favorites email to friend print save as pdf

Related Stories

Pertussis reaches epidemic level in Washington state

Jul 20, 2012

(HealthDay) -- Pertussis rates may reach record levels this year in the United States, where Washington state is experiencing an ongoing epidemic, according to a report published in the July 20 issue of the ...

Incidence and reproduction numbers of pertussis

Jun 22, 2010

Analyses of serological and social contact data from five European countries by Mirjam Kretzschmar and colleagues show that childhood vaccination against Bordetella pertussis (whooping cough) has shifted the burden of inf ...

Recommended for you

19 new dengue cases in Japan, linked to Tokyo park

6 minutes ago

Japan is urging local authorities to be on the lookout for further outbreaks of dengue fever, after confirming another 19 cases that were contracted at a popular local park in downtown Tokyo.

Liberia's airport battles to contain Ebola

21 hours ago

With the last rays of sunlight speckling the departures area at Liberia's international airport, passengers queue patiently to go through medical screening designed to show up the Ebola virus.

User comments