Pertactin-negative Bordetella pertussis identified in U.S.

Pertactin-negative <i>Bordetella pertussis</i> identified in U.S.
Pertactin-negative variants of Bordetella pertussis have been identified in the United States; and children who receive diphtheria-tetanus-whole-cell pertussis priming have lower reported rates of pertussis, according to correspondence published in the Feb. 7 issue of the New England Journal of Medicine.

(HealthDay)—Pertactin-negative variants of Bordetella pertussis have been identified in the United States; and children who receive diphtheria-tetanus-whole-cell pertussis (DTwP) priming have lower reported rates of pertussis, according to correspondence published in the Feb. 7 issue of the New England Journal of Medicine.

Noting an increase in the numbers of cases of pertussis in several countries, including the United States, despite increased vaccination, Anne Marie Queenan, Ph.D., from Janssen Research and Development in Raritan, N.J., and colleagues examined the contribution of pertactin-negative variants of B. pertussis. The researchers found that 11 of 12 isolates of B. pertussis cultured from specimens from children hospitalized in Philadelphia were negative for pertactin.

Juventila Liko, M.D., M.P.H., from the Oregon Health Authority in Portland, and colleagues examined the effectiveness of first-dose DTwP priming in children fully immunized with --acellular pertussis (DTaP) beyond their first year or life and in those who received a DTaP booster. Using data from April 1997 through July 2012, 484 cases of pertussis were reported, 402 of which were matched to the Oregon immunization information system ALERT IIS. The researchers found that the reported rates of pertussis were lower among children who had started the vaccination process with DTwP. Higher rates of reported pertussis were seen for children who underwent priming with acellular versus whole-cell pertussis.

"The balance between vaccine side effects and effectiveness needs to be considered in developing and implementing recommendations on pertussis vaccination, particularly in light of recent outbreaks of pertussis," Liko and colleagues write.

More information: Full Text - Queenan
Full Text - Liko

add to favorites email to friend print save as pdf

Related Stories

Pertussis reaches epidemic level in Washington state

Jul 20, 2012

(HealthDay) -- Pertussis rates may reach record levels this year in the United States, where Washington state is experiencing an ongoing epidemic, according to a report published in the July 20 issue of the ...

Incidence and reproduction numbers of pertussis

Jun 22, 2010

Analyses of serological and social contact data from five European countries by Mirjam Kretzschmar and colleagues show that childhood vaccination against Bordetella pertussis (whooping cough) has shifted the burden of inf ...

Recommended for you

US orders farms to report pig virus infections

13 hours ago

The U.S. government is starting a new program to help monitor and possibly control the spread of a virus that has killed millions of pigs since showing up in the country last year.

Foreigner dies of MERS in Saudi

14 hours ago

A foreigner has died after she contracted MERS in the Saudi capital, the health ministry said on announced Friday, bringing the nationwide death toll to 73.

Vietnam battles fatal measles outbreak

18 hours ago

Vietnam is scrambling to contain a deadly outbreak of measles that has killed more than 100 people, mostly young children, and infected thousands more this year, the government said Friday.

New clues on tissue scarring in scleroderma

18 hours ago

A discovery by Northwestern Medicine scientists could lead to potential new treatments for breaking the cycle of tissue scarring in people with scleroderma.

User comments