New rabies vaccine could reduce cost, risk

by April Reese Sorrow

(Medical Xpress)—Researchers at the University of Georgia used a common dog disease-canine parainfluenza-to build a new vaccine to protect humans and animals from the rabies virus. Developers hope the new treatment will reduce costs and increase accessibility to a vaccine for a disease that currently kills 55,000 people a year.

Current vaccines use weakened pathogens to develop resistance. UGA professor Biao He's technique is different. Using genetic engineering, he and his team of researchers inserted a non-viral piece of the into parainfluenza virus 5, called PIV5, which a virus that causes respiratory infection in dogs. Using PIV5 as a delivery mechanism to expose humans and other animals to important pathogens-rabies in this case-allows them to create antibodies that will protect against future infections.

"This could be man's new best friend in delivering vaccines," said He, who is a professor of infectious diseases in the UGA College of Veterinary Medicine and the study's lead author.

According to results recently published in the , the vaccine is effective in building immunity. The study tested the efficacy of the drug on a mouse model when administered orally, through the nose and into muscle. When the mice were administered a lethal dose of rabies, survival was 100 percent when they had received the vaccine nasally or into muscle. Survival was 50 percent when the vaccine was administered orally.

"This is first report of an orally effective candidate in animals based on PIV5 as a vector," said He, who also is a Georgia Research Alliance distinguished investigator and member of the Faculty of Infectious Diseases. "These results indicate this is an excellent candidate for a new generation of recombinant rabies vaccine for humans and animals, and PIV5 is a potential vector for oral vaccines."

In the U.S., rabies are seen most often in wild animal populations. The reports an average of two human deaths per year from rabies in the U.S.

While death rates in the U.S. are low, rabies is expensive to control. The CDC estimates the disease costs more than $300 million annually, costs that include the vaccination of companion animals, animal control programs, maintenance of rabies laboratories and medical costs. Humans at risk for contracting rabies, like those who work with wild , even if immunized need booster shots after the fact if a rabid animal bites them. Humans infected with rabies who have not been vaccinated pay high prices for medical treatment that is time consuming and painful.

He is hopeful the new vaccine will be more effective and will require less of the drug to create resistance, reducing the cost.

"The virus we are using as a vector has been used as a component for kennel cough vaccines, so we know how to mass-produce it. And, we also know that manufacturing it won't be a problem in terms of producing a large quantity at a cheaper price," He said. "This becomes very important in areas where resources are limited."

Initial results from canine tests look very promising. He hopes the vaccine will be available for animals in three to five years. Human vaccines will take longer.

"We are doing various things using the platform technology," He said. "What we are really good at is re-engineering them to make them do the things we like them to do. So, we are looking at different kinds of pathogens to develop into form, and so far we have been very fortunate that many of them worked really well. Some of them worked better than I would have imagined."

He's lab also is working on vaccines for HIV, tuberculosis and malaria using this technology.

"That is the fun part of science: You come up ideas, and of course it takes a long time to push it through, and sometimes what you thought would work doesn't, but sometimes it works out really well, and that is really exciting and fun," He said.

More information: Fu, Z. et al. jvi.asm.org/content/early/2012… c1-b86b-dafd8af65f51

Related Stories

Single vaccines to protect against both rabies and Ebola

Aug 25, 2011

Researchers from Thomas Jefferson University, among other institutions, including the National Institute of Allergy and Infectious Diseases, have developed single vaccines to protest against both rabies and ...

New rabies vaccine may require only a single shot... not six

Sep 18, 2009

A person, usually a child, dies of rabies every 20 minutes. However, only one inoculation may be all it takes for rabies vaccination, according to new research published in the Journal of Infectious Diseases by researchers at the ...

Recommended for you

How the world is underestimating Ebola: WHO

1 hour ago

The Ebola epidemic tearing through western Africa is by far the deadliest known outbreak of the disease, yet the magnitude of the spread is believed to be severely underestimated.

Last Ebola-free region of Liberia falls to virus

1 hour ago

Every region of Liberia has now been hit by Ebola, officials said Friday, as the World Health Organization warned the fight against the worst-ever outbreak of the killer disease would take months.

Ebola death toll rises to 1,427: WHO

12 hours ago

The death toll from the Ebola outbreak sweeping through west African countries has risen to 1,427 out of more than 2,600 cases, the World Health Organization said Friday.

User comments