Stem cell source an important factor, impacting ability to treat myocardial infarction
When a research team from Denmark and Sweden compared the therapeutic capabilities of adipose-derived stem cells (ASCs) versus bone marrow-derived stem cells (BMSCs) obtained from a single 84 year-old male donor with ischemic coronary disease to regeneratively treat myocardial infarction in a rat model, they found that the ASCs preserved more cardiac function in the test rats while neither stem cell type induced myocardial angiogenesis (blood vessel growth.)
The study appears as an early e-publication for the journal Cell Transplantation.
"Treatment of myocardial infarction with bone marrow-derived mesenchymal stem cells (BM-MSCs) and adipose-derived stem cells has shown promising results," said study co-author Dr. Trine Fink. "The transplantation of MSCs in treating myocardial infarction (MI) has been shown to improve left ventricular function in animal models. In this study, we compared the effects of adipose-derived stem cells and BMSCs from an elderly male suffering from coronary atherosclerosis when the donated cells were transplanted randomly, without the administration of immunosuppressant drugs, into two groups of adult rats modeled with MI."
The researchers noted that the age and health status of cell donors are important factors and that the impact of cell transplantation using cells from elderly patients with cardiac ischemia "needs to be elucidated."
The researchers found that ASCs ameliorated heart failure following MI in the group receiving ASCs while the group receiving the BMSCs received no similar benefit. They found that the BMSCs secreted a significantly larger amount of vascular endothelial growth factor, VEGF, than the ASCs, but that did not result in a better angiogenic response. In addition, the group receiving ASCs had improved left ventricular fraction.
That neither stem cell group induced myocardial angiogenesis raised questions about whether donor age and health have an effect on the efficacy of stem cells used in treating myocardial infarction, said the researchers.
"While this study supported previous findings that ASCs are less prone to diminish in numbers and efficacy with aging when compared to BMSCs, the characteristics of MSCs from elderly patients suffering from coronary atherosclerosis need to be determined," they concluded.
More information: www.ingentaconnect… 921rasmussen
Journal reference: Cell Transplantation
- Study suggests different organ-derived stem cell injections improve heart function Nov 27, 2012 | not rated yet | 0
- Repairing cartilage with fat: Problems and potential solutions Aug 24, 2012 | not rated yet | 0
- Scientists uncover the potential to control adult stem cells Apr 10, 2008 | not rated yet | 0
- Can stem cells heal damaged hearts? No easy answers, but some signs of hope Oct 08, 2008 | not rated yet | 0
- Bone marrow stem cell co-transplantation prevents embryonic stem cell transplant-associated tumors May 11, 2009 | not rated yet | 0
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Why is zone 1 in liver more prone to ischemic injury?
3 hours ago Hi, Is it because around central vein, there is only deoxygenated blood from the vein where as in the periphery there is hepatic artery. Also why...
How can there be villous adenoma in colon, if there are no villi there
May 22, 2013 As title suggest. Thanks :smile:
How can there be a term called "intestinal metaplasia" of stomach
May 21, 2013 Hello everyone, Ok Stomach's normal epithelium is simple columnar, now in intestinal type of adenocarcinoma of stomach it undergoes "intestinal...
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
- More from Physics Forums - Medical Sciences
More news stories
Every day, their baby stopped breathing, his collapsed bronchus blocking the crucial flow of air to his lungs. April and Bryan Gionfriddo watched helplessly, just praying that somehow the dire predictions ...
Medical research 14 hours ago | 5 / 5 (2) | 0
The human gut is loaded with commensal bacteria – "good" microbes that, among other functions, help the body digest food. The gastrointestinal tract contains literally trillions of such cells, and yet the ...
Medical research 18 hours ago | 5 / 5 (3) | 0 |
Medical research 18 hours ago | 4.9 / 5 (10) | 1 |
On May 22, JoVE will publish details of a technique to measure the health of human genetic material in relation to a patient's age. The method is demonstrated by the laboratory of Dr. Gil Atzmon at New York's Albert Einste ...
Medical research 22 hours ago | not rated yet | 0
(Medical Xpress)—Scientists supported by the National Institutes of Health have a new theory as to why a woman's fertility declines after her mid-30s. They also suggest an approach that might help slow ...
Medical research 23 hours ago | not rated yet | 0 |
(Medical Xpress)—Researchers at the University of Virginia School of Medicine have identified a promising target for treating glioblastoma, one that appears to avoid many of the obstacles that typically frustrate efforts ...
18 minutes ago | not rated yet | 0 |
(Medical Xpress)—The first symptoms of major depression may be behavioral, but the common mental illness is based in biology—and not limited to the brain.
13 minutes ago | not rated yet | 0 |
(Medical Xpress)—Scientists at Emory Vaccine Center have shown that an immune regulatory molecule called IL-21 is needed for long-lasting antibody responses in mice against viral infections.
7 minutes ago | not rated yet | 0 |
Human breastmilk responds quickly to protect the child when there is an infection in mothers or babies, according to new international research led by The University of Western Australia.
19 minutes ago | not rated yet | 0
To coincide with the broadcast of Jabbed: Love, Fear and Vaccines (SBS ONE, Sunday 26 May at 8.30pm) the first ever national survey on Australian attitudes to vaccination reveals surprising statistics including half of Australians ...
45 seconds ago | not rated yet | 0