American Academy of Microbiology releases resistance report
What do cancer cells, weeds, and pathogens have in common? They all evolve resistance to the treatments that are supposed to eliminate them. However, researchers developing the next generation of antibiotics, herbicides, and anti-cancer therapeutics rarely come together to explore the common evolutionary principles at work across their different biological systems.
The new American Academy of Microbiology report "Moving Targets: Fighting Resistance in Infections, Pests, and Cancer" concludes that scientists working on different kinds of treatments have much to learn from each other. Applying lessons learned about the evolution of resistance in different biological systems during the earliest stages of drug and pesticide design could lead to more effective treatments for patients, farmers, and public health organizations.
Do you think the oncologists at a cutting-edge research hospital ever sit down with local farmers? Do you think the pharmaceutical researchers developing the next generation of anti-HIV drugs spend any time with the plant scientists working on the next generation of Roundup Ready soybeans? If your answer to both questions is no, you would be mostly right. Even though all of these people are dealing with exactly the same evolutionary phenomena, they do not recognize themselves as a single scientific community and rarely get a chance to learn from each other. What they all have in common is that they are trying to eliminate an unwanted living entity but the treatments they develop eventually lose effectiveness because the target evolves resistance.
The emergence of resistance is a phenomenon with ancient evolutionary roots, although the human role in triggering resistance was little appreciated before the advent of widespread antibiotic and pesticide use in the 1950s. In Silent Spring, the prescient Rachel Carson wrote in 1962 that "by their very nature chemical controls are self-defeating, for they have been devised and applied without taking into account the complex biological systems against which they have been blindly hurled." Sadly, in the fifty years since Silent Spring was published, biologists, doctors, and farmers continue to be plagued with resistance evolution by the species they seek to control. This phenomenon is witnessed in medicine in the emergence of antibiotic resistance and when tumors become intractable to standard anti-cancer medications, in agriculture when insecticides and herbicides lose effectiveness, and in public health when disease-carrying insects develop resistance to control strategies. The report "Moving Targets: Fighting Resistance in Infections, Pests, and Cancer" makes clear that a multi-disciplinary approach to the phenomenon of resistance can be very powerful.
More information: A PDF of Moving Targets can be found here: bit.ly/XaKaSY.
Provided by American Society for Microbiology
- Misuse of antibiotics not the only cause of resistance says report Oct 15, 2009 | not rated yet | 0
- Drugs used to overcome cancer may also combat antibiotic resistance: researchers Dec 22, 2011 | not rated yet | 0
- Tracking the evolution of antibiotic resistance Feb 01, 2013 | not rated yet | 0
- Economics and evolution help scientists identify new strategy to control antibiotic resistance Mar 18, 2011 | not rated yet | 0
- Newly discovered reservoir of antibiotic resistance genes Oct 21, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011 I'd like to open a discussion thread for version 2 of the draft of my book ''Classical and Quantum Mechanics via Lie algebras'', available online at http://lanl.arxiv.org/abs/0810.1019 , and for the...
- More from Physics Forums - Independent Research
More news stories
Early use of tracheostomy for mechanically ventilated patients not associated with improved survival
For critically ill patients receiving mechanical ventilation, early tracheostomy (within the first 4 days after admission) was not associated with an improvement in the risk of death within 30 days compared to patients who ...
Other 4 hours ago | not rated yet | 0
The decision to limit life support in patients in the intensive care unit (ICU) appears to be significantly influenced by physician practices and/or the culture of the hospital, suggests new findings from researchers at the ...
Other 6 hours ago | not rated yet | 0
Knee replacement surgery is a very common procedure. However, it does not always resolve function or pain in all the recipients of new knees. A study by Robert Barrack, MD and his colleagues from the Washington University ...
Other 8 hours ago | not rated yet | 0
Doctors are trained to think "common disease" when they meet patients in their practices, and as they rarely or never meet a rare disease, it often takes many years to reach the right diagnosis. A new search tool called FindZebra ...
Other 8 hours ago | not rated yet | 0
Delayed transfer to the intensive care unit (ICU) in hospitalized patients significantly increases the risk of dying in the hospital, according to a new study from researchers in Chicago.
Other 10 hours ago | not rated yet | 0
(Medical Xpress)—Native peoples in regions where cameras are uncommon sometimes react with caution when their picture is taken. The fear that something must have been stolen from them to create the photo ...
9 hours ago | 4 / 5 (4) | 0 |
An experimental sleeping pill from US drug company Merck is effective at helping people fall and stay asleep, according to reviewers at the US Food and Drug Administration, which could soon approve the new drug.
2 hours ago | 5 / 5 (1) | 0
Activating an enzyme known to play a role in the anti-aging benefits of calorie restriction delays the loss of brain cells and preserves cognitive function in mice, according to a study published in the May ...
3 hours ago | 5 / 5 (3) | 0 |
(Medical Xpress)—Despite spending billions of dollars on research and development, drug companies have been unable to come up with effective treatments for dementia and Alzheimer's Disease (AD). Now, A. ...
6 hours ago | 4.8 / 5 (6) | 0 |
A drug commonly used to treat depression and anxiety may improve a stress-related heart condition in people with stable coronary heart disease, according to researchers at Duke Medicine.
4 hours ago | not rated yet | 0 |
Australian scientists have charted the path of insulin action in cells in precise detail like never before. This provides a comprehensive blueprint for understanding what goes wrong in diabetes.
8 hours ago | 4.7 / 5 (3) | 0 |