Enhanced brain acetate metabolism may reward heavy drinkers

March 8, 2013

In addition to its well-known effects on the CNS, alcohol consumption has a significant impact on metabolism. After consumption, the body rapidly begins converting ethanol to acetate, which can serve as an energy source for the brain and other organs. Lihong Jiang and colleagues at Yale University used a brain imaging technique, magnetic resonance spectroscopy, to track acetate uptake and metabolism in the brains of heavy drinkers (consumed at least 8 drinks/week) and light drinkers (consumed less than 2 drinks/week).

n this issue of the Journal of Clinical Investigation, they report that heavy drinkers had greater, more rapid acetate uptake and metabolism compared to light drinkers. Because ethanol consumption can cause acute drops in , acetate has the potential to provide a compensatory energetic reward. Additionally, acetate metabolism produces adenosine, which has a sedating effect similar to alcohol.

These findings suggest that the provision of acetate and/or enhancement of adenosine during alcohol detoxification could help alleviate withdrawal symptoms.

Explore further: The effects of smoking and alcohol use on risk of upper aero-digestive cancers

More information: Increased brain uptake and oxidation of acetate in heavy drinkers, J Clin Invest. doi:10.1172/JCI65153.

Related Stories

Recommended for you

Alcoholics may lack key enzyme

September 22, 2016

(HealthDay)—Alcoholics may lack an enzyme that would help them control their impulse to drink, a new study with rats suggests.

Gamblers more prone to violent behavior

September 6, 2016

Men who gamble are more likely to act violently towards others, with the most addicted gamblers the most prone to serious violence, new research has shown.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.