Cell-cycle progression panel identifies prostate cancer risk

Cell-cycle progression panel identifies prostate cancer risk
The cell-cycle progression gene panel is useful to improve the risk stratification for men with even low-risk, clinically localized prostate cancer, according to research published online March 4 in the Journal of Clinical Oncology.

(HealthDay)—The cell-cycle progression (CCP) gene panel is useful to improve the risk stratification for men with even low-risk, clinically localized prostate cancer, according to research published online March 4 in the Journal of Clinical Oncology.

Matthew R. Cooperberg, M.D., M.P.H., of the University of California in San Francisco, and colleagues sought to validate a previously described genetic called CCP (that provides a value calculated from the average expression of 31 CCP genes) and its ability to improve in men with localized prostate cancer and predict recurrence after prostatectomy.

The researchers found that for each increase of one unit in the CCP score, the hazard ratio increased by 1.7, after adjusting for the patient's Cancer of the Prostate Risk Assessment Post-Surgical (CAPRA-S) score. Combining the CCP with the CAPRA-S score yielded consistently predictive outcomes across a range of clinical risk, including low-risk patients.

"The performance of the CCP score in this validation study was excellent," the authors write. "The score provided independent prognostic information after and may prove useful in helping guide decisions with respect to adjuvant treatment and in stratifying men for future adjuvant therapy studies."

Several authors disclosed financial ties to genetics firms. Myriad Genetics helped support the study.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Prostate cancer clinical stage does not predict recurrence

Nov 22, 2010

A new study challenges the current staging system that determines the extent or severity of prostate cancer that has not metastasized. Published early online in Cancer, a peer-reviewed journal of the American Cancer Societ ...

Recommended for you

Immune checkpoint inhibitors may work in brain cancers

Nov 21, 2014

New evidence that immune checkpoint inhibitors may work in glioblastoma and brain metastases was presented today by Dr Anna Sophie Berghoff at the ESMO Symposium on Immuno-Oncology 2014 in Geneva, Switzerland.

New model of follow up for breast cancer patients

Nov 21, 2014

Public health researchers from the University of Adelaide have evaluated international breast cancer guidelines, finding that there is potential to improve surveillance of breast cancer survivors from both a patient and health ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.