Did evolution give us inflammatory disease?

In new research published on March 21, 2013 in the online issue of The American Journal of Human Genetics, researchers from Brigham and Women's Hospital (BWH) demonstrate that some variants in our genes that contribute to a person's risk for inflammatory diseases such as multiple sclerosis, Crohn's disease or rheumatoid arthritis, have been the target of natural selection over the course of human history.

The research team, led by Philip De Jager, MD, PhD, BWH Department of Neurology and Barbara Stranger, PhD, University of Chicago, looked at genome-wide association studies along with protein- networks, as well as other data and found 21 places in the genome that bear a 'signature' for both inflammatory disease susceptibility and natural selection.

Towfique Raj, PhD, BWH Department of Neurology, is the lead author on this study. The study's findings suggest that, in the past, these variants rose in frequency in the human population to help protect humans against viruses, bacteria and other pathogens. But now in our modern world, the environment and exposure to pathogens has changed, and the genetic variants that were originally meant to protect us, now make an autoimmune reaction more likely. These results are consistent with the in which our cleaner environment is thought to contribute to the increasing prevalence of inflammatory diseases.

More information: www.cell.com/AJHG/abstract/S0002-9297(13)00109-2

Related Stories

Genetic risk for uterine fibroids discovered

date Oct 04, 2012

Uterine fibroids are the most common type of pelvic tumors in women and are the leading cause of hysterectomy in the United States. Researchers from Brigham and Women's Hospital (BWH) are the first to discover a genetic risk ...

Recommended for you

Team discovers key step in how taste buds regenerate

date 14 hours ago

Researchers at the University of Colorado Anschutz Medical Campus have discovered a key molecular pathway that aids in the renewal of taste buds, a finding that may help cancer patients suffering from an ...

How mutations in a high risk gene affect motor neurons

date 20 hours ago

Scientists at the flagship motor neuron disease research centre, based at the University of Sheffield, investigated how specialised nerve cells that control voluntary movements die – something which is ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.