FSH, inhibin B poor predictors of sperm count after cancer

March 8, 2013
FSH, inhibin B poor predictors of sperm count after cancer
Serum levels of follicle-stimulating hormone and inhibin B are not good predictors of sperm levels in male survivors of childhood cancer, according to a study published online Feb. 19 in the Journal of Clinical Oncology.

(HealthDay)—Serum levels of follicle-stimulating hormone (FSH) and inhibin B are not good predictors of sperm levels in male survivors of childhood cancer, according to a study published online Feb. 19 in the Journal of Clinical Oncology.

Daniel M. Green, M.D., from the St. Jude Children's Research Hospital in Memphis, Tenn., and colleagues investigated the association of of FSH and inhibin B with sperm concentration in 275 adult male survivors of childhood cancer who had received gonadotoxic treatment placing them at risk of azoospermia.

Based on receiver operating characteristic analysis, the researchers chose 11.5 mIU/mL FSH and 31 ng/L inhibin B as cutoffs. Using these cutoffs to identify azoospermic survivors, they found that serum FSH levels had a specificity of 74.1 percent and a of 65.1 percent, while serum inhibin B levels had a specificity of 45.0 percent and a positive predictive value of 52.1 percent.

"Neither serum inhibin B nor FSH is a suitable surrogate for determination of sperm concentration in a semen sample," Green and colleagues conclude.

Explore further: New weekly fertility injections work as well as daily

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

New weekly fertility injections work as well as daily

June 12, 2012

New long-lasting weekly injections of fertility hormones are as safe and effective as standard daily injections, according to Cochrane researchers. The researchers compared weekly and daily hormone injections in a Cochrane ...

Men who do exercise produce better quality semen

October 31, 2012

A new study conducted by researchers at the University of Cordoba links moderate physical activity in males with better hormone levels and sperm characteristics that favour reproduction compared to sedentary men.

Increased serum metal levels after lumbar disc replacement

December 22, 2012

(HealthDay)—Serum metal levels of cobalt and chromium are elevated at all postoperative time points up to 36 months following metal-on-metal lumbar disc replacement, according to research published in the November issue ...

Recommended for you

Scientists find leukemia's surroundings key to its growth

February 10, 2016

Researchers at The University of Texas at Austin have discovered that a type of cancer found primarily in children can grow only when signaled to do so by other nearby cells that are noncancerous. The finding, published in ...

Study examines evolution of cancer

February 8, 2016

A novel Yale study answers age-old questions about how cancers spread by applying tools from evolutionary biology. The new insights will help scientists better understand the genetic origins of tumor metastases, and lead ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.