FSH, inhibin B poor predictors of sperm count after cancer

FSH, inhibin B poor predictors of sperm count after cancer
Serum levels of follicle-stimulating hormone and inhibin B are not good predictors of sperm levels in male survivors of childhood cancer, according to a study published online Feb. 19 in the Journal of Clinical Oncology.

(HealthDay)—Serum levels of follicle-stimulating hormone (FSH) and inhibin B are not good predictors of sperm levels in male survivors of childhood cancer, according to a study published online Feb. 19 in the Journal of Clinical Oncology.

Daniel M. Green, M.D., from the St. Jude Children's Research Hospital in Memphis, Tenn., and colleagues investigated the association of of FSH and inhibin B with sperm concentration in 275 adult male survivors of childhood cancer who had received gonadotoxic treatment placing them at risk of azoospermia.

Based on receiver operating characteristic analysis, the researchers chose 11.5 mIU/mL FSH and 31 ng/L inhibin B as cutoffs. Using these cutoffs to identify azoospermic survivors, they found that serum FSH levels had a specificity of 74.1 percent and a of 65.1 percent, while serum inhibin B levels had a specificity of 45.0 percent and a positive predictive value of 52.1 percent.

"Neither serum inhibin B nor FSH is a suitable surrogate for determination of sperm concentration in a semen sample," Green and colleagues conclude.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

New hormone data can predict menopause within a year

Oct 27, 2008

For many women, including the growing number who choose later-in-life pregnancy, predicting their biological clock's relation to the timing of their menopause and infertility is critically important.

Men who do exercise produce better quality semen

Oct 31, 2012

A new study conducted by researchers at the University of Cordoba links moderate physical activity in males with better hormone levels and sperm characteristics that favour reproduction compared to sedentary ...

New weekly fertility injections work as well as daily

Jun 12, 2012

New long-lasting weekly injections of fertility hormones are as safe and effective as standard daily injections, according to Cochrane researchers. The researchers compared weekly and daily hormone injections in a Cochrane ...

Sperm may be harmed by exposure to BPA, study suggests

Aug 03, 2010

(PhysOrg.com) -- In one of the first human studies of its kind, researchers have found that urinary concentrations of the controversial chemical Bisphenol A, or BPA, may be related to decreased sperm quality and sperm concentration.

Recommended for you

Cancer: Tumors absorb sugar for mobility

3 hours ago

Cancer cells are gluttons. We have long known that they monopolize large amounts of sugar. More recently, it became clear that some tumor cells are also characterized by a series of features such as mobility or unlikeliness ...

Early hormone therapy may be safe for women's hearts

12 hours ago

(HealthDay)—Healthy women at low risk of cardiovascular disease may be able to take hormone replacement therapy soon after menopause for a short time without harming their hearts, according to a new study.

Low yield for repeat colonoscopy in some patients

13 hours ago

(HealthDay)—Repeat colonoscopies within 10 years are of little benefit to patients who had no polyps found on adequate examination; however, repeat colonoscopies do benefit patients when the baseline examination was compromised, ...

Cell's recycling center implicated in division decisions

16 hours ago

Most cells do not divide unless there is enough oxygen present to support their offspring, but certain cancer cells and other cell types circumvent this rule. Researchers at The Johns Hopkins University have now identified ...

User comments