Study finds up to half of gestational diabetes patients will develop type 2 diabetes
Women who were diagnosed with gestational diabetes during pregnancy face a significantly higher risk of developing Type 2 diabetes in the future, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).
The prospective cohort study tracked 843 women who were diagnosed with gestational diabetes between 1996 and 2003 at Cheil General Hospital in Seoul, South Korea. About 12.5 percent of the women developed Type 2 diabetes within two months of delivering their babies. During the next decade, the number of women diagnosed with Type 2 diabetes continued to grow at a rate of 6.8 percent a year.
"The findings indicate as many as half of Asian women who had gestational diabetes will develop Type 2 diabetes within eight years of giving birth," said the study's lead author, Soo Heon Kwak, MD, of Seoul National University Hospital.
The study is among the largest of its kind to study Asian women who had gestational diabetes. Researchers followed 370 participants for more than a year after the birth of their children. Of the remaining women studied, 105 were diagnosed with type 2 diabetes within two months of giving birth and the remainder did not participate in long-term follow-up visits.
Researchers identified two distinct groups of women who were at risk – those who developed Type 2 diabetes within two months of giving birth and those who took a year or more to progress to a Type 2 diabetes diagnosis. Although obesity was a major risk factor for both groups, researchers found genetic variations that could explain the timing of the disease's onset.
Women who rapidly developed Type 2 diabetes had a significant defect in insulin secretion. Among this population, researchers found a variation in the HHEX (hematopoietically expressed homeobox) gene that is associated with Type 2 diabetes.
Women who were slower to develop Type 2 diabetes were more likely to have a variation in the CDKAL1 gene, which also has been linked to Type 2 diabetes.
More research into genetic and environmental risk factors is needed to develop models that can better predict who will develop Type 2 diabetes, Kwak said. In the meantime, women who had gestational diabetes should undergo regular blood sugar testing.
"It is crucial for women who had gestational diabetes to have their blood sugar levels checked two months after giving birth and annually thereafter," Kwak said. "In addition to the problems undiagnosed Type 2 diabetes poses to the mother, leaving the disease untreated increases the risk of any future children developing congenital disorders."
More information: The article, "Clinical and Genetic Risk Factors for Type 2 Diabetes at Early or Late Post-partum after Gestational Diabetes Mellitus," appears in the April 2013 issue of JCEM.
Journal reference: Journal of Clinical Endocrinology & Metabolism
Provided by The Endocrine Society
- Birth records hold pancreatic cancer clue Aug 16, 2007 | not rated yet | 0
- Women's risk of heart disease after gestational diabetes differs by race Jun 06, 2011 | not rated yet | 0
- Researchers find evidence of periodontal disease leading to gestational diabetes Mar 24, 2008 | not rated yet | 0
- Study finds diabetes doubling before motherhood Apr 28, 2008 | not rated yet | 0
- Cancer prevalence higher with long duration of diabetes Jan 24, 2013 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Does a charged particle rotate when traveling through a static Bf?
1 hour ago I have been looking at mass spectrometers, in particular the interactions between the Bf ind of a charged particle in motion in a static Bf of the...
Find a link between physics and assignment problems
2 hours ago Hi ! I've been working about assignments problems and how to solve them. I will have to do a presentation about it in few weeks. However, I'll...
Light as a source of electricity
2 hours ago Hello Dear Fellows! We all know that light is an electromagnetic wave and also we know that an antenna receives EM waves and...
A question about the energy stored in a capacitor.
2 hours ago If we imagine a simple circuit with a battery and a capacitor with negligible internal resistance, the capacitor is charged up to a point where the...
Electric field-Charge inside a metallic shell
4 hours ago I am having few doubts while studying electric field which i am putting here Suppose there is a spherical metallic shell with point charge q1 at...
Change in momentum when a body is thrown up and falls back down.
11 hours ago Say, a body of mass 'm' is thrown at a certain angle with the vertical with certain initial velocity 'u'. The initial momentum of this object is mu....
- More from Physics Forums - Classical Physics
More news stories
(HealthDay)—Moderate aerobic exercise prevents fructose-induced hypertriglyceridemia in healthy males, according to a study published online May 14 in Diabetes.
Diabetes May 17, 2013 | 5 / 5 (1) | 0 |
A DNA variant near a digestive enzyme does not only affect risk of developing diabetes but also affects the response to treatment, an international consortium of researchers including the University of Dundee has found.
Diabetes May 17, 2013 | not rated yet | 0 |
(Medical Xpress)—Development of a sophisticated artificial pancreas holds potential to transform the lives of patients with Type 1 diabetes.
Diabetes May 16, 2013 | 5 / 5 (1) | 0 |
A small University at Buffalo study has found for the first time that in Type 1 diabetics, insulin injections exert a strong anti-inflammatory effect at the cellular and molecular level, while even small amounts of glucose ...
Diabetes May 16, 2013 | not rated yet | 0
(HealthDay)—Home diabetes regimens partially explain the increased risk of having a hypoglycemia event during hospitalization among older African-American men with diabetes, according to a study published ...
Diabetes May 14, 2013 | not rated yet | 0
Researchers at the University of Wisconsin have identified a potential new risk factor for obstructive sleep apnea: asthma. Using data from the National Institutes of Health (Heart, Lung, and Blood Institute)-funded Wisconsin ...
1 hour ago | not rated yet | 0 |
A new study looking at sleep-disordered breathing (SDB) and markers for Alzheimer's disease (AD) risk in cerebrospinal fluid (CSF) and neuroimaging adds to the growing body of research linking the two.
1 hour ago | not rated yet | 0 |
In their quest to learn more about the variability of cells between and within tissues, biomedical scientists have devised tools capable of simultaneously measuring dozens of characteristics of individual ...
2 hours ago | 5 / 5 (1) | 0 |
Scientists at Johns Hopkins have turned their view of osteoarthritis (OA) inside out. Literally. Instead of seeing the painful degenerative disease as a problem primarily of the cartilage that cushions joints, ...
2 hours ago | 5 / 5 (1) | 0 |
Gourmands and foodies everywhere have long recognized ginger as a great way to add a little peppery zing to both sweet and savory dishes; now, a study from researchers at Columbia University shows purified components of the ...
1 hour ago | not rated yet | 0
The hunt for an HIV vaccine has gobbled up $8 billion in the past decade, and the failure of the most recent efficacy trial has delivered yet another setback to 26 years of efforts.
6 hours ago | not rated yet | 0