Key variables examined in gestational diabetes advance

Key variables examined in gestational diabetes advance
For women with gestational diabetes mellitus, clinical and genetic factors including higher pre-pregnancy body mass index are associated with development of type 2 diabetes mellitus, according to a study published online March 7 in the Journal of Clinical Endocrinology.

(HealthDay)—For women with gestational diabetes mellitus (GDM), clinical and genetic factors including higher pre-pregnancy body mass index are associated with development of type 2 diabetes mellitus (T2DM), according to a study published online March 7 in the Journal of Clinical Endocrinology.

Soo Heon Kwak, M.D., from the Seoul National University Hospital in Korea, and colleagues conducted a hospital-based that enrolled 843 women with GDM to examine the clinical and that are associated with the development of early or late T2DM.

The researchers found that 12.5 percent of subjects had T2DM at two months postpartum (early converters). Late converters included a further 23.8 percent of the remaining 370 subjects who developed T2DM during more than one year of follow-up. Higher pre-pregnancy body mass index, higher area under the curve of glucose during an antepartum , lower fasting insulin concentration, and decreased beta-cell function were independent risk factors for early converters. Higher pre-pregnancy and higher glucose area under the curve were independent risk factors for late converters. Early conversion was associated with variants in CDKN2A/2B and HHEX, while late conversion correlated with variants in CDKAL1.

"In conclusion, a significant portion of GDM subjects progress to T2DM in the early postpartum period and continue to have a high incidence of T2DM at later periods," the authors write. "This strongly supports the current recommendation that GDM women be tested for their glucose tolerance status at two months postpartum and annually thereafter."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Low adiponectin in first trimester linked to GDM

Feb 01, 2013

(HealthDay)—Low adiponectin levels during the first trimester of pregnancy correlate with a higher level of insulin resistance and an increased risk of developing gestational diabetes mellitus (GDM), according ...

Gestational diabetes, obesity impact pregnancy outcomes

Mar 02, 2012

(HealthDay) -- Women with gestational diabetes mellitus (GDM) who are obese have significantly higher odds of adverse pregnancy outcomes, according to findings from the multinational Hyperglycemia and Adverse ...

Hip circumference inversely tied to diabetes risk

Sep 18, 2012

(HealthDay)—There is an inverse relationship between hip circumference and risk of type 2 diabetes mellitus (T2DM), according to a meta-analysis published online Sept. 3 in Obesity Reviews.

Recommended for you

Low-carb diet recommended for diabetics

Jul 29, 2014

A new study involving researchers from the University of Alabama at Birmingham and other institutions says patients with Type 1 and Type 2 diabetes should eat a diet low in carbohydrates.

Shift work linked to heightened risk of type 2 diabetes

Jul 24, 2014

Shift work is linked to a heightened risk of developing type 2 diabetes, with the risk seemingly greatest among men and those working rotating shift patterns, indicates an analysis of the available evidence published online ...

User comments