Low-risk bladder cancer rarely progresses to muscle invasion

Low-risk bladder cancer rarely progresses to muscle invasion
Low-risk bladder cancer rarely progresses to muscle invasion but is associated with an increased risk of disease-specific mortality compared with matched populations, according to research published in the March issue of The Journal of Urology.

(HealthDay)—Low-risk bladder cancer rarely progresses to muscle invasion but is associated with an increased risk of disease-specific mortality compared with matched populations, according to research published in the March issue of The Journal of Urology.

Kate D. Linton, of the University of Sheffield in the United Kingdom, and colleagues examined the risk of disease-specific mortality in 699 patients with primary, low-risk, noninvasive (G1pTa) who were followed for a median of 61 months.

During follow-up, the researchers found that 17 patients died of bladder cancer, including 13 of 14 who displayed progression to muscle invasion and four of 19 who exhibited grade progression to high-grade, nonmuscle . Tumor weight and low-grade dysplasia in the initial resection specimen were found to be significantly associated with disease-specific mortality. In these patients, the rate of disease-specific mortality was five times higher than in age and gender matched general populations.
"The rate of progression to muscle invasion and disease-specific mortality in patients with low-risk bladder cancer is low but higher than in the general population," the authors write. "Current surveillance regimens failed to detect advancing disease in time to alter its natural history. While a is necessary to robustly confirm our findings, these observations question current surveillance regimens."

One author disclosed a financial tie to GlaxoSmithKline; the study was partially supported by a GlaxoSmithKline SK Clinician Scientist fellowship.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Gender, BMI impact bladder perforation during resection

Apr 17, 2012

(HealthDay) -- For patients with bladder tumors, female gender, low body mass index, and tumor characteristics correlate with the risk of bladder perforation during transurethral resection, according to research ...

Patients unaware of link between smoking and bladder cancer

Jul 08, 2008

Even though cigarette smoking accounts for up to half of all bladder cancer cases, few people are aware of the connection – including more than three-quarters of patients who have bladder cancer, according to a new study ...

Recommended for you

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.