Study identifies multiple genetic factors impacting development of nearsightedness
In the largest ever genome-wide association study on myopia, 23andMe, the leading personal genetics company, identified 20 new genetic associations for myopia, or nearsightedness. The company also replicated two known associations in the study, which was specific to individuals of European ancestry. The study included an analysis of genetic data and survey responses from more than 50,000 23andMe customers and demonstrates that the genetic basis of myopia is complex and affected by multiple genes.
Myopia is the most common eye disorder worldwide. In the United States, an estimated 30 to 40 percent of the adult population is nearsighted. Myopia is a refractive error that results primarily from increased axial length of the eye. The increased physical length of the eye relative to optical length causes images to be focused in front of the retina, resulting in blurred distance vision.
The study, titled "Genome-Wide Analysis Points to Roles for Extracellular Matrix Remodeling, the Visual Cycle, and Neuronal Development in Myopia" was published on February 28, 2013 in PLOS Genetics, an open-access, peer-reviewed journal.
Although environmental factors (such as level of education, outdoor exposure, reading, and "near work" or fine detail work that requires close focus of the eyes) are implicated in the development of myopia, it is well established that genetics play a substantial role as well. The identification of these 20 novel genetic associations shows that several new genetic pathways play a role in the development of human myopia, including extracellular remodeling, the visual cycle, eye and body growth, retinal neuron development and general neuronal development or signaling.
"This study highlights the potential importance of early neuronal development in the progression of myopia and opens the door for additional research into the complex interactions that underlie vision development," said Nicholas Eriksson, Ph.D., author and 23andMe principal scientist.
Based on the findings of this study, 23andMe has launched a new research survey designed to provide insights that may expand understanding of the genetics of eyesight more broadly.
More information: www.plosgenetics.o… pgen.1003299
Journal reference: PLoS Genetics
Provided by 23andMe Inc.
- 24 new genes for short-sightedness identified Feb 10, 2013 | not rated yet | 0
- Clear-sighted research identifies genes for eye problems Feb 21, 2013 | not rated yet | 0
- Colour vision link may help myopia research Mar 01, 2013 | not rated yet | 0
- Specialty contact lenses may one day help halt the progression of nearsightedness in children Oct 02, 2012 | not rated yet | 0
- Researchers identify gene that leads to myopia (nearsightedness) Sep 01, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011 I'd like to open a discussion thread for version 2 of the draft of my book ''Classical and Quantum Mechanics via Lie algebras'', available online at http://lanl.arxiv.org/abs/0810.1019 , and for the...
- More from Physics Forums - Independent Research
More news stories
Two mutations central to the development of infantile myofibromatosis (IM)—a disorder characterized by multiple tumors involving the skin, bone, and soft tissue—may provide new therapeutic targets, according to researchers ...
Genetics May 24, 2013 | 3 / 5 (2) | 0 |
Can human genes be patented? That was the question posed by Alan J. Snyder, vice president and associate provost for research and graduate studies at Lehigh, and Lee Kaplan, scientific director of cellular and molecular genetics ...
Genetics May 24, 2013 | 4 / 5 (1) | 0
Researchers from Queen Mary, University of London have led the largest sequencing study of human disease to date, investigating the genetic basis of six autoimmune diseases.
Genetics May 22, 2013 | 4.5 / 5 (4) | 0 |
University of Minnesota Medical School researchers from the Masonic Cancer Center, University of Minnesota, in partnership with the University's Brain Tumor Program, have developed a new mouse model of malignant peripheral ...
Genetics May 20, 2013 | 5 / 5 (1) | 0 |
Northwestern University scientists have shown a gene involved in neurodegenerative disease also plays a critical role in the proper function of the circadian clock.
Genetics May 16, 2013 | 3 / 5 (1) | 1 |
Coenzyme Q10 decreases all cause mortality by half, according to the results of a multicentre randomised double blind trial presented today at Heart Failure 2013 congress. It is the first drug to improve heart failure mortality ...
12 hours ago | 5 / 5 (2) | 5
(HealthDay)—Animals make great companions for senior citizens, but elderly people who always drive with a pet in the car are far more likely to crash than those who never drive with a pet, researchers have ...
4 hours ago | not rated yet | 0
Heart failure accelerates the aging process and brings on early andropausal syndrome (AS), according to research presented today at the Heart Failure Congress 2013. AS, also referred to as male 'menopause', was four times ...
12 hours ago | not rated yet | 1
Mortality and length of stay are highest in heart failure patients admitted in January, on Friday, and overnight, according to research presented today at the Heart Failure Congress 2013. The analysis of nearly 1 million ...
12 hours ago | not rated yet | 0
(AP)—Department of Justice lawyers have again asked a federal appeals court in New York to delay lifting age restrictions and prescription requirements on an emergency contraceptive popularly known as the morning-after ...
12 hours ago | not rated yet | 0