Neonatal size unaffected by gestational diabetes drugs

Neonatal size unaffected by gestational diabetes drugs
Women with gestational diabetes mellitus treated with metformin or insulin have similar changes in markers of metabolic status and no differences in offspring birth weight, according to a study published in the March issue of Diabetes Care.

(HealthDay)—Women with gestational diabetes mellitus treated with metformin or insulin have similar changes in markers of metabolic status and no differences in offspring birth weight, according to a study published in the March issue of Diabetes Care.

Helen L. Barrett, M.B.B.S., from the University of Queensland in Herston, Australia, and colleagues examined the association between circulating maternal and neonatal markers of metabolic status (glucose, lipids, C-reactive protein) with infant size at birth in women with gestational diabetes mellitus, where 236 women had been randomly assigned to metformin and 242 had been randomly assigned to insulin.

The researchers found that women treated with metformin had a significantly greater increase in triglycerides at 36 weeks of gestation (21.93 versus 9.69 percent). There were no other differences between treatment groups for maternal or neonatal metabolic markers or neonatal anthropometry. After adjusting for possible confounding variables, including maternal , a birth weight in the >90th percentile was associated with markers of , maternal , and triglycerides, while a birth weight in the <10th percentile was associated with triglycerides.

"There were few differences in circulating maternal and neonatal markers of metabolic status and no differences in measures of anthropometry between the offspring of women treated with metformin and the offspring of women treated with insulin," Barrett and colleagues conclude.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Gestational diabetes, obesity impact pregnancy outcomes

Mar 02, 2012

(HealthDay) -- Women with gestational diabetes mellitus (GDM) who are obese have significantly higher odds of adverse pregnancy outcomes, according to findings from the multinational Hyperglycemia and Adverse ...

Recommended for you

Blood glucose levels set for achieving HbA1c targets

Apr 11, 2014

(HealthDay)—The average self-monitored blood glucose (SMBG) concentrations needed at premeal, postmeal, and bedtime have been established to achieve a range of hemoglobin A1c (HbA1c) targets, according ...

Women with diabetes less likely to have a mammogram

Apr 11, 2014

Women with diabetes are 14 per cent less likely to be screened for breast cancer compared to women without diabetes, according to a study by researchers at the Institute for Clinical Evaluative Sciences (ICES) and Women's ...

Nonalcoholic fatty liver disease linked to CKD in T1DM

Apr 09, 2014

(HealthDay)—For patients with type 1 diabetes, nonalcoholic fatty liver disease (NAFLD) is independently associated with the risk of incident chronic kidney disease (CKD), according to a study published ...

Common diabetes treatment could extend hypoglycaemia

Apr 08, 2014

(Medical Xpress)—Researchers at the University of Adelaide have discovered that a common treatment for people with type 2 diabetes could cause longer-than-normal periods of the low blood sugar reaction hypoglycaemia, which ...

User comments