Researchers identify Parkinson's disease link
Patricia Trimmer, Ph.D., associate professor of anatomy and neurobiology and associate director of basic research for the Parkinson’s and Movement Disorders Center, and a member of her research team, graduate student Emily Cronin-Furman, take a closer look at at Lewy bodies found in the cells made from patients with sporadic Parkinson's disease.
(Medical Xpress)—Researchers at the Virginia Commonwealth University Parkinson's and Movement Disorders Center have found that mitochondrial quality and functional capacity play an important role in Parkinson's disease.
Patricia Trimmer, Ph.D., associate professor of anatomy and neurobiology and associate director of basic research for the Parkinson's and Movement Disorders Center, and her research team used human cell lines containing mitochondrial DNA from Parkinson's disease, or PD, patients to understand how mitochondrial dysfunction and Lewy bodies (diagnostic markers found in the brains of deceased individuals who had Parkinson's disease) are involved in sporadic PD.
The research team used a human cytoplasmic hybrid, or cybrid, cell model to express mitochondrial DNA from individuals with sporadic PD to compare mitochondrial function in parent cell lines to cell lines enriched for the expression of Lewy bodies. The team expected a consistent improvement or loss of function in all of the cell lines enriched for Lewy bodies.
Different outcomes were discovered among the three cell lines enriched for Lewy bodies. One line showed improved function, one showed loss of function and one was unchanged. To find out why this happened, the mitochondrial quality, movement and functional capacity were examined to determine if there were any changes in the cell lines enriched for Lewy bodies.
The major finding of this study was the discovery that the mitochondrial DNA in cells with Lewy bodies determined if the enriched cells would be healthier, sicker or unchanged, not the Lewy bodies, as the team had hypothesized. The Lewy body-enriched cells with mitochondrial DNA were more functional than cells with lower levels of mitochondrial DNA.
These results demonstrated that mitochondrial DNA plays an important role in sporadic PD.
"This finding is an important piece of the puzzle in finding better treatments for Parkinson's disease," said Trimmer. "These results support our hypothesis that mitochondrial DNA play an important role in sporadic PD, and the next step will be to figure out what that role is."
Trimmer and her team plan to further explore the role of mitochondrial DNA in cell function and its impacts on PD.
This study was published in the Journal of Molecular Neurodegeneration and can be read online: www.molecularneuro… ntent/8/1/6# .
Provided by Virginia Commonwealth University
- Seeds of destruction in Parkinson's disease: Spread of diseased proteins kills neurons Oct 05, 2011 | not rated yet | 0
- New research helps explain genetics of Parkinson's disease Nov 24, 2008 | not rated yet | 0
- Parkinson's disease protein causes disease spread and neuron death in healthy animals Nov 15, 2012 | not rated yet | 0
- Researchers develop stem cell-based models for studying mitochondrial disorders Sep 23, 2011 | not rated yet | 0
- Study first to link mitochondrial dysfunction and alpha-Synuclein multiplication in human fibroblasts Oct 06, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
latitude & longitude & air pressure
1 hour ago Hi there, I have a peculiar question. Imagine that you are in a earth position, obtained by google, that gives you the latitude and longitude....
Differences of Classical Mechanics when learned with Calc vs algebra?
4 hours ago what are the differences? Every example I find usually has a derivative or integral or some kind of calculus defined concept that seems to make it...
what is the distance traveled
8 hours ago Hi. I have newly started to study mechanical physics. based on study, I conduct a simple experiment. But unfortunately i am unable apply the laws in...
Image of a Convex Lens Cut in Half Horizontally
12 hours ago Hello everyone, A friend of mine came up with this question in class and I really do not have a good answer. Suppose you have a convex lens...
Ray tracing throught optical system of thick lenses
12 hours ago Can you advise me a free software that allow to draw rays passed throught system of thick lenses (preferable in 3D)?
Faraday's law on circular wire
13 hours ago In my examples on Faraday's law in my book, they use a drawing of a magnet approaching a circular wire. The changing magnetic flux then induces an...
- More from Physics Forums - Classical Physics
More news stories
Parkinson's disease (PD) is a degenerative neurological disorder marked by a progressive loss of motor control. Despite intensive research, there are currently no approved therapies that have been demonstrated to alter the ...
Parkinson's & Movement disorders May 20, 2013 | not rated yet | 0
Faulty energy production in brain cells leads to disorders ranging from Parkinson's to intellectual disability
Neuroscientist Patrik Verstreken of VIB (Flanders Institute for Biotechnology) and KU Leuven has shown for the first time that dysfunctional mitochondria in brain cells can lead to learning disabilities. The link between ...
Parkinson's & Movement disorders May 17, 2013 | 4 / 5 (2) | 0
McGill University researchers have unlocked a new door to developing drugs to slow the progression of Parkinson's disease. Collaborating teams led by Dr. Edward A. Fon at the Montreal Neurological Institute and Hospital -The ...
Parkinson's & Movement disorders May 09, 2013 | 5 / 5 (1) | 0 |
New research reveals that Solanaceae—a flowering plant family with some species producing foods that are edible sources of nicotine—may provide a protective effect against Parkinson's disease. The study appearing today ...
Parkinson's & Movement disorders May 09, 2013 | not rated yet | 0
(Medical Xpress)—Researchers at the Stanford University School of Medicine have exposed the possible function, in the healthy brain, of a mysterious molecule that has been strongly implicated in Parkinson's ...
Parkinson's & Movement disorders May 01, 2013 | 5 / 5 (3) | 0 |
Swiss scientists reveal the mechanism responsible for aging hidden deep within mitochondria—and dramatically slow it down in worms by administering antibiotics to the young.
8 hours ago | 4.7 / 5 (3) | 0 |
Researchers from Queen Mary, University of London have led the largest sequencing study of human disease to date, investigating the genetic basis of six autoimmune diseases.
8 hours ago | not rated yet | 0 |
(HealthDay)—Migraines and depression can each cause a great deal of suffering, but new research indicates the combination of the two may be linked to something else entirely—a smaller brain.
4 hours ago | 5 / 5 (1) | 0 |
Until now, little was scientifically known about the human potential to cultivate compassion—the emotional state of caring for people who are suffering in a way that motivates altruistic behavior.
5 hours ago | 5 / 5 (1) | 2 |
A new approach for immunizing against influenza elicited a more potent immune response and broader protection than the currently licensed seasonal influenza vaccines when tested in mice and ferrets. The vaccine ...
5 hours ago | not rated yet | 0 |
(HealthDay)—Implementation of systematic monitoring for medication adherence will allow for identification of barriers to adherence and tailoring of interventions, according to a viewpoint piece published ...
3 hours ago | not rated yet | 0