Vitamin D linked to mitochondrial oxidative function

SfE/BES: vitamin D linked to mitochondrial oxidative function
For vitamin D deficient individuals, cholecalciferol therapy is associated with reduced phosphocreatine recovery half-time in skeletal muscle and with improvements in fatigue, according to a study presented at the annual meeting of the Society for Endocrinology/British Endocrine Societies, held from March 18 to 21 in Harrogate, U.K.

(HealthDay)—For vitamin D deficient individuals, cholecalciferol therapy is associated with reduced phosphocreatine recovery half-time in skeletal muscle and with improvements in fatigue, according to a study presented at the annual meeting of the Society for Endocrinology/British Endocrine Societies, held from March 18 to 21 in Harrogate, U.K.

Akash Sinha, M.B.B.S., from Newcastle University in the United Kingdom, and colleagues conducted a longitudinal study to examine the effect of cholecalciferol therapy on skeletal mitochondrial oxidative function in the gastroc-soleus compartment in 12 symptomatic, vitamin D deficient individuals. Phosphocreatine recovery kinetics were assessed using phosphorus-31 measurements in cases before and after treatment with cholecalciferol and in 15 healthy controls.

The researchers found that following cholecalciferol therapy there was a significant reduction in phosphocreatine recovery half-time, indicating an improvement in maximal . This correlated with improvements in mean serum 25-hydroxyvitamin D (25[OH]D) levels. At rest, there was no difference seen in phosphate metabolites. Decreasing 25(OH)D levels correlated with increasing phosphocreatine recovery half-time. An improvement in fatigue was noted by all patients following cholecalciferol therapy.

"This is the first time a link has been shown between vitamin D status and muscle aerobic function," Sinha said in a statement. "Patients with often experience symptoms of . Our findings in a small group of patients with very low vitamin D levels show that muscle efficiency significantly improves when vitamin D status is improved."

More information: Abstract
More Information

Related Stories

Vitamin D tied to muscle power in adolescent girls

date Feb 03, 2009

Vitamin D is significantly associated with muscle power and force in adolescent girls, according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

Treating vitamin D deficiency may improve depression

date Jun 25, 2012

Women with moderate to severe depression had substantial improvement in their symptoms of depression after they received treatment for their vitamin D deficiency, a new study finds. The case report series to be presented ...

Recommended for you

Europe's police crack massive horsemeat trafficking ring

date Apr 25, 2015

Police from seven European countries detained 26 people in a crackdown on a horsemeat trafficking ring two years after a tainted meat scandal that rocked the continent, the EU's judicial agency Eurojust said Saturday.

Text messaging useful for reaching 'at-risk' teens about sex

date Apr 24, 2015

Text messaging that connects teens with sexual health educators is effective for delivering sexual health information, according to a recent study in The Edward R. Murrow College of Communication at Washington State University.The ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.