Vitamin D linked to mitochondrial oxidative function

SfE/BES: vitamin D linked to mitochondrial oxidative function
For vitamin D deficient individuals, cholecalciferol therapy is associated with reduced phosphocreatine recovery half-time in skeletal muscle and with improvements in fatigue, according to a study presented at the annual meeting of the Society for Endocrinology/British Endocrine Societies, held from March 18 to 21 in Harrogate, U.K.

(HealthDay)—For vitamin D deficient individuals, cholecalciferol therapy is associated with reduced phosphocreatine recovery half-time in skeletal muscle and with improvements in fatigue, according to a study presented at the annual meeting of the Society for Endocrinology/British Endocrine Societies, held from March 18 to 21 in Harrogate, U.K.

Akash Sinha, M.B.B.S., from Newcastle University in the United Kingdom, and colleagues conducted a longitudinal study to examine the effect of cholecalciferol therapy on skeletal mitochondrial oxidative function in the gastroc-soleus compartment in 12 symptomatic, vitamin D deficient individuals. Phosphocreatine recovery kinetics were assessed using phosphorus-31 measurements in cases before and after treatment with cholecalciferol and in 15 healthy controls.

The researchers found that following cholecalciferol therapy there was a significant reduction in phosphocreatine recovery half-time, indicating an improvement in maximal . This correlated with improvements in mean serum 25-hydroxyvitamin D (25[OH]D) levels. At rest, there was no difference seen in phosphate metabolites. Decreasing 25(OH)D levels correlated with increasing phosphocreatine recovery half-time. An improvement in fatigue was noted by all patients following cholecalciferol therapy.

"This is the first time a link has been shown between vitamin D status and muscle aerobic function," Sinha said in a statement. "Patients with often experience symptoms of . Our findings in a small group of patients with very low vitamin D levels show that muscle efficiency significantly improves when vitamin D status is improved."

More information: Abstract
More Information

add to favorites email to friend print save as pdf

Related Stories

Vitamin D tied to muscle power in adolescent girls

Feb 03, 2009

Vitamin D is significantly associated with muscle power and force in adolescent girls, according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

Treating vitamin D deficiency may improve depression

Jun 25, 2012

Women with moderate to severe depression had substantial improvement in their symptoms of depression after they received treatment for their vitamin D deficiency, a new study finds. The case report series to be presented ...

Recommended for you

Jamaica Senate starts debate on pot decriminalization bill

11 hours ago

Jamaica's Senate on Friday started debating a bill that would decriminalize possession of small amounts of pot and establish a licensing agency to regulate a lawful medical marijuana industry on the island where the drug ...

Can Lean Management improve hospitals?

17 hours ago

Waiting times in hospital emergency departments could be cut with the introduction of Lean Management and Six Sigma techniques according to new research.

Research finds 90 percent of home chefs contaminate food

18 hours ago

If you're gearing up for a big Super Bowl bash, you might want to consult the best food-handling practices before preparing that feast. New research from Kansas State University finds that most home chefs drop the ball on ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.