Vitamin D linked to mitochondrial oxidative function

SfE/BES: vitamin D linked to mitochondrial oxidative function
For vitamin D deficient individuals, cholecalciferol therapy is associated with reduced phosphocreatine recovery half-time in skeletal muscle and with improvements in fatigue, according to a study presented at the annual meeting of the Society for Endocrinology/British Endocrine Societies, held from March 18 to 21 in Harrogate, U.K.

(HealthDay)—For vitamin D deficient individuals, cholecalciferol therapy is associated with reduced phosphocreatine recovery half-time in skeletal muscle and with improvements in fatigue, according to a study presented at the annual meeting of the Society for Endocrinology/British Endocrine Societies, held from March 18 to 21 in Harrogate, U.K.

Akash Sinha, M.B.B.S., from Newcastle University in the United Kingdom, and colleagues conducted a longitudinal study to examine the effect of cholecalciferol therapy on skeletal mitochondrial oxidative function in the gastroc-soleus compartment in 12 symptomatic, vitamin D deficient individuals. Phosphocreatine recovery kinetics were assessed using phosphorus-31 measurements in cases before and after treatment with cholecalciferol and in 15 healthy controls.

The researchers found that following cholecalciferol therapy there was a significant reduction in phosphocreatine recovery half-time, indicating an improvement in maximal . This correlated with improvements in mean serum 25-hydroxyvitamin D (25[OH]D) levels. At rest, there was no difference seen in phosphate metabolites. Decreasing 25(OH)D levels correlated with increasing phosphocreatine recovery half-time. An improvement in fatigue was noted by all patients following cholecalciferol therapy.

"This is the first time a link has been shown between vitamin D status and muscle aerobic function," Sinha said in a statement. "Patients with often experience symptoms of . Our findings in a small group of patients with very low vitamin D levels show that muscle efficiency significantly improves when vitamin D status is improved."

More information: Abstract
More Information

add to favorites email to friend print save as pdf

Related Stories

Vitamin D tied to muscle power in adolescent girls

Feb 03, 2009

Vitamin D is significantly associated with muscle power and force in adolescent girls, according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

Treating vitamin D deficiency may improve depression

Jun 25, 2012

Women with moderate to severe depression had substantial improvement in their symptoms of depression after they received treatment for their vitamin D deficiency, a new study finds. The case report series to be presented ...

Recommended for you

Emergency department nurses aren't like the rest of us

1 hour ago

(Medical Xpress)—Emergency department nurses aren't like the rest of us - they are more extroverted, agreeable and open - attributes that make them successful in the demanding, fast-paced and often stressful environment ...

Many patients don't understand electronic lab results

1 hour ago

(Medical Xpress)—While it's becoming commonplace for patients to see the results of lab work electronically, a new University of Michigan study suggests that many people may not be able to understand what ...

Healthier foods available in neighborhoods

3 hours ago

Changes to the federal food assistance program for low-income women and their children improved the availability of healthy foods at small and medium-size stores in New Orleans, according to research from ...

Adherence to diet can be measured from blood

3 hours ago

(Medical Xpress)—New results from the Nordic SYSDIET study show that it's possible to assess dietary compliance from a blood sample. This is especially useful in controlled dietary intervention studies investigating the ...

User comments