C-peptide levels linked to death and heart disease in nondiabetic adults

High blood levels of the serum C-peptide are linked to heart disease and death in people without diabetes, according to a large study published in CMAJ (Canadian Medical Association Journal).

Researchers looked at data from the Third Nutrition and Health Examination Survey (NHANES III) and the NHANES III Linked Mortality File to determine the link between C-peptide and death from all causes as well as from heart disease. They looked at on 5902 adults aged 40 years or older representative of the US population. People with high serum C-peptide levels (higher than 1.018 nmol/L) had a 1.8- to 3.2-fold increased risk of death from all causes as well as cardiovascular disease–specific death compared with people with low C-peptide levels (lower than 0.440 nmol/L). The risk increased as C-peptide levels increased.

"We found a significant association between serum C-peptide levels and risk of all-cause, cardiovascular-related disease and coronary artery–related mortality among adults without diabetes," writes Dr. Kyoung-bok Min, Department of Occupational and Environmental Medicine, Ajou University School of Medicine, Suwon, Republic of Korea, with coauthor.

The study authors found that C-peptide levels were better at predicting mortality than other measures such as glycated hemoglobin and fasting . Although the reason for the increased risk of death has not been determined, the authors suggest it may be because of the relationship between C-peptide levels and risk factors for atherogenic vascular issues.

"Our findings support the potential relevance of serum C-peptide as a predictor of adverse and indicate that elevated C-peptide levels may be an important predictive marker of an increased risk of death," they conclude.

More information: www.cmaj.ca/lookup/doi/10.1503/cmaj.121950

add to favorites email to friend print save as pdf

Related Stories

Glucose levels at admission predict death in pneumonia

May 30, 2012

(HealthDay) -- For patients with community-acquired pneumonia without preexisting diabetes, serum glucose levels at admission are predictive of death at 28 and 90 days, according to a study published online ...

Recommended for you

Where Ebola battles are won

1 hour ago

(HealthDay)—Four hospitals that are home to advanced biocontainment facilities have become America's ground zero in the treatment of Ebola patients.

Depression tied to worse lumbar spine surgery outcomes

4 hours ago

(HealthDay)—Depressive symptoms are associated with poorer long-term outcome in patients undergoing surgery for lumbar spinal stenosis (LSS), according to research published in the Oct. 1 issue of The Sp ...

Ebola death toll edging to 4,900 mark: WHO

4 hours ago

The death toll in the world's worst-ever Ebola outbreak has edged closer to 4,900, while almost 10,000 people have now been infected, new figures from the World Health Organization showed Wednesday.

US to track everyone coming from Ebola nations

5 hours ago

U.S. authorities said Wednesday that everyone traveling into the U.S. from Ebola-stricken nations will be monitored for symptoms for 21 days. That includes returning American aid workers, federal health employees ...

User comments