C-peptide levels linked to death and heart disease in nondiabetic adults

High blood levels of the serum C-peptide are linked to heart disease and death in people without diabetes, according to a large study published in CMAJ (Canadian Medical Association Journal).

Researchers looked at data from the Third Nutrition and Health Examination Survey (NHANES III) and the NHANES III Linked Mortality File to determine the link between C-peptide and death from all causes as well as from heart disease. They looked at on 5902 adults aged 40 years or older representative of the US population. People with high serum C-peptide levels (higher than 1.018 nmol/L) had a 1.8- to 3.2-fold increased risk of death from all causes as well as cardiovascular disease–specific death compared with people with low C-peptide levels (lower than 0.440 nmol/L). The risk increased as C-peptide levels increased.

"We found a significant association between serum C-peptide levels and risk of all-cause, cardiovascular-related disease and coronary artery–related mortality among adults without diabetes," writes Dr. Kyoung-bok Min, Department of Occupational and Environmental Medicine, Ajou University School of Medicine, Suwon, Republic of Korea, with coauthor.

The study authors found that C-peptide levels were better at predicting mortality than other measures such as glycated hemoglobin and fasting . Although the reason for the increased risk of death has not been determined, the authors suggest it may be because of the relationship between C-peptide levels and risk factors for atherogenic vascular issues.

"Our findings support the potential relevance of serum C-peptide as a predictor of adverse and indicate that elevated C-peptide levels may be an important predictive marker of an increased risk of death," they conclude.

More information: www.cmaj.ca/lookup/doi/10.1503/cmaj.121950

add to favorites email to friend print save as pdf

Related Stories

Glucose levels at admission predict death in pneumonia

May 30, 2012

(HealthDay) -- For patients with community-acquired pneumonia without preexisting diabetes, serum glucose levels at admission are predictive of death at 28 and 90 days, according to a study published online ...

Recommended for you

The hidden burden of dengue fever in West Africa

7 hours ago

Misdiagnosis of febrile illnesses as malaria is a continuing problem in Africa. A new study shows that in Ghana, dengue fever is circulating in urban areas and going undiagnosed. The authors of the study hope to use the findings ...

Teenager with stroke symptoms actually had Lyme disease

7 hours ago

A Swiss teenager, recently returned home from a discotheque, came to the emergency department with classic sudden symptoms of stroke, only to be diagnosed with Lyme disease. The highly unusual case presentation was published ...

Understanding lung disease in aboriginal Australians

8 hours ago

A new study has confirmed that Aboriginal Australians have low forced vital capacity—or the amount of air that can be forcibly exhaled from the lungs after taking the deepest breath possible. The finding may account for ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.