Drug-facilitated weight loss benefits cardiometabolic status

April 12, 2013
Drug-facilitated weight loss benefits cardiometabolic status
Obese and overweight patients with dyslipidemia or hypertension treated with phentermine and topiramate extended-release (PHEN/TPM ER) for weight loss had significant improvements in cardiovascular disease risk factors, according to research published in the April 15 issue of The American Journal of Cardiology.

(HealthDay)—Obese and overweight patients with dyslipidemia or hypertension treated with phentermine and topiramate extended-release (PHEN/TPM ER) for weight loss had significant improvements in cardiovascular disease risk factors, according to research published in the April 15 issue of The American Journal of Cardiology.

Michael H. Davidson, M.D., of University of Chicago, and colleagues conducted a subgroup analysis of subjects with either hyperlipidemia or hypertension who participated in the CONQUER study, a randomized, double-blind, placebo-controlled, multi-center study, to determine changes in cardiometabolic risk factors in subjects treated with PHEN/TPM ER.

According to the researchers, in a subgroup of 647 patients with dyslipidemia or hypertension, treatment with either low or high dose of PHEN/TPM ER resulted in significantly greater percentage weight loss than patients treated with placebo. Independent of treatments, significantly greater reductions in triglycerides (-14.5 percent to -39.8 percent) and non-high-density lipoprotein cholesterol (-9.4 percent to -14.8 percent) were observed in patients with dyslipidemia who lost ≥ 5 percent of their weight than those who lost < 5 percent of their baseline weight. Patients with hypertension who lost ≥ 5 percent of their weight also had significantly greater reductions in systolic blood pressure (-7.5 to -11.8 mm Hg).

"The dose-related weight loss induced by PHEN/TPM ER, the associated beneficial effects on cardiometabolic risk factors, and the reductions in medication use indicate that PHEN/TPM ER treatment may be an important addition to the therapeutic armamentarium for obese and with comorbidities such as hypertension and dyslipidemia," the authors write.

The study was supported by VIVUS, Inc., Mountain View, California and several authors disclosed with pharmaceutical and biotechnology companies.

Explore further: ECO: New weight loss drug effective in advanced obesity

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

ECO: New weight loss drug effective in advanced obesity

May 14, 2012

(HealthDay) -- A new combination treatment of controlled-release phentermine/topiramate (PHEN/TPM CR) leads to significantly greater weight loss than a placebo even in individuals with significant obesity-related comorbidities, ...

Experimental drug helps diabetes patients lose weight

June 25, 2012

An experimental drug helped significantly more overweight patients with diabetes shed pounds, compared with placebo, a new study finds. The results will be presented at The Endocrine Society's 94th Annual Meeting in Houston.

Pediatric kidney disease tied to abnormal carotid arteries

September 28, 2012

(HealthDay)—Ultrasound measurements of carotid intima-media thickness (cIMT) are significantly elevated among children with chronic kidney disease (CKD) compared with healthy controls, according to a study published online ...

Recommended for you

Painkillers linked to heart failure: study

September 29, 2016

Widely used prescription and non-prescription painkillers are associated with an increased risk of hospital admission for heart failure, according to a study released Thursday.

Researchers mine Twitter for cardiovascular disease research

September 28, 2016

For years, marketers and other commercial data-miners have been using Twitter's vast database of "tweets" to gauge consumer attitudes and track events. Now medical researchers are getting in on the trend. Researchers from ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.