Nothing fishy about it: Fish oil can boost the immune system

Fish oil rich in DHA and EPA is widely believed to help prevent disease by reducing inflammation, but until now, scientists were not entirely sure about its immune enhancing effects. A new report appearing in the April 2013 issue of the Journal of Leukocyte Biology, helps provide clarity on this by showing that DHA-rich fish oil enhances B cell activity, a white blood cell, challenging the notion that fish oil is only immunosuppressive. This discovery is important as it shows that fish oil does not necessarily reduce the overall immune response to lower inflammation, possibly opening the doors for the use of fish oil among those with compromised immune systems.

"Fish oil may have immune enhancing properties that could benefit immunocompromised individuals," said Jenifer Fenton, Ph.D., M.P.H., a researcher involved in the work from the Department of Food Science and Human Nutrition at Michigan State University in East Lansing, Michigan.

To make this discovery, researchers used two groups of mice. One group was fed a control diet, and the other was fed a diet supplemented with DHA-rich fish oil for five weeks. were harvested from several tissues and then stimulated in culture. Researchers then looked for markers of B cell activation on the cell surface, B cell membrane changes, and B cell cytokine production. They found that DHA-enriched fish oil enhanced B cell activation and select , which may actually aid immune responses associated with pathogen clearance, while possibly dampening the totality of the inflammatory response.

"This work confirms similar findings on fish oil and B cells from our lab, and moves us one step closer to understanding the immune enhancing properties of EPA and DHA," said S. Raza Shaikh, Ph.D., a researcher also involved in the work from the Department of Biochemistry and Molecular Biology at East Carolina University.

More information: Eric A. Gurzell, Heather Teague, Mitchel Harris, Jonathan Clinthorne, Saame Raza Shaikh, and Jenifer I. Fenton. DHA-enriched fish oil targets B cell lipid microdomains and enhances in vivo and ex vivo B cell function. J Leukoc Biol April 2013 93:463-470; doi:10.1189/jlb.0812394

add to favorites email to friend print save as pdf

Related Stories

Fish oil linked to increased risk of colon cancer in mice

Oct 05, 2010

Fish oil – long encouraged by doctors as a supplement to support heart and joint health, among other benefits – induced severe colitis and colon cancer in mice in research led by Michigan State University and published ...

Nothing fishy about fish oil fortified nutrition bars

Sep 25, 2012

In today's fast-paced society, consumers often reach for nutrition bars when looking for a healthy on-the-go snack. A new study in the September issue of the Journal of Food Science published by the Institute of Food Techno ...

Recommended for you

New hay fever blood test nothing to sneeze at

Sep 29, 2014

(Medical Xpress)—Brisbane researchers have developed a blood test that can accurately detect one of the commonest causes of hay fever, paving the way for new treatments.

Geisel researchers contribute to study of trained immunity

Sep 26, 2014

A study published in the journal science provides support for a new—and still controversial—understanding of the immune system. the research was conducted by collaborators in the U.S. and Europe, including Robert Cramer ...

User comments