Gene variants link to insulin resistance based on diet

April 28, 2013
Gene variants link to insulin resistance based on diet
Variants of insulin receptor substrate 1 (IRS1) are associated with insulin resistance and metabolic syndrome, but only under particular dietary conditions, according to a study published online April 17 in Diabetes Care.

(HealthDay)—Variants of insulin receptor substrate 1 (IRS1) are associated with insulin resistance and metabolic syndrome, but only under particular dietary conditions, according to a study published online April 17 in Diabetes Care.

Ju-Sheng Zheng, from Zhejiang University in Hangzhou, China, and colleagues examined two IRS1 variants (rs7578326 and rs2943641) linked to type 2 diabetes and their association with , related traits, and diet in 820 individuals of European ancestry and 844 individuals of Puerto Rican ancestry.

The researchers found a lower risk of insulin resistance, type 2 diabetes, and metabolic syndrome in rs7578326 G-allele carriers and rs2943641 T-allele carriers. In both groups, the risk of metabolic syndrome was lower in rs7578326 G-allele carriers, but only when dietary were below the median intake of each group. In the group with , the risk of insulin resistance and metabolic syndrome were lower in rs7578326 G-allele carriers and rs2943641 T-allele carriers and their haplotype G-T carriers, but only when the dietary saturated fatty acid-to-carbohydrate ratio was low.

"IRS1 variants are associated with insulin resistance and related traits and are modulated by diet in two populations of different ancestries," Zheng and colleagues conclude.

Explore further: High blood glucose levels may increase kidney disease in elderly populations

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Amino acid levels linked to type 2 diabetes risk

May 9, 2012

(HealthDay) -- Levels of some amino acids are associated with glycemia and insulin resistance and predict the development of type 2 diabetes in men, according to a study published online May 2 in Diabetes.

Insulin receptor substrate 1 variant linked to GFR

June 1, 2012

(HealthDay) -- A variant of the human insulin receptor substrate 1 (IRS1) gene, which plays an important role in modulating tissue response to insulin, is significantly associated with glomerular filtration rate (GFR), according ...

Genetic variant is linked to obesity and insulin resistance

June 26, 2012

A large study in people at risk of diabetes has found a direct association between the presence of a small genetic alteration in a hormone receptor and increased body fat and insulin resistance. The results, to be presented ...

Recommended for you

Diets avoiding dry-cooked foods can protect against diabetes

August 24, 2016

Simple changes in how we cook could go a long way towards preventing diabetes, say researchers at the Icahn School of Medicine at Mount Sinai. A new randomized controlled trial, published online July 29 in the journal Diabetologia, ...

New study reveals a novel protein linked to type 2 diabetes

August 16, 2016

Findings from Boston University School of Medicine (BUSM), which appear in eLife, provide a possible explanation as to why most people who are obese develop insulin resistance and type 2 diabetes. A minority of obese individuals, ...

Gene variant explains differences in diabetes drug response

August 9, 2016

The first results from a large international study of patients taking metformin, the world's most commonly used type 2 diabetes drug, reveal genetic differences among patients that may explain why some respond much better ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.