Gene variants link to insulin resistance based on diet

April 28, 2013
Gene variants link to insulin resistance based on diet
Variants of insulin receptor substrate 1 (IRS1) are associated with insulin resistance and metabolic syndrome, but only under particular dietary conditions, according to a study published online April 17 in Diabetes Care.

(HealthDay)—Variants of insulin receptor substrate 1 (IRS1) are associated with insulin resistance and metabolic syndrome, but only under particular dietary conditions, according to a study published online April 17 in Diabetes Care.

Ju-Sheng Zheng, from Zhejiang University in Hangzhou, China, and colleagues examined two IRS1 variants (rs7578326 and rs2943641) linked to type 2 diabetes and their association with , related traits, and diet in 820 individuals of European ancestry and 844 individuals of Puerto Rican ancestry.

The researchers found a lower risk of insulin resistance, type 2 diabetes, and metabolic syndrome in rs7578326 G-allele carriers and rs2943641 T-allele carriers. In both groups, the risk of metabolic syndrome was lower in rs7578326 G-allele carriers, but only when dietary were below the median intake of each group. In the group with , the risk of insulin resistance and metabolic syndrome were lower in rs7578326 G-allele carriers and rs2943641 T-allele carriers and their haplotype G-T carriers, but only when the dietary saturated fatty acid-to-carbohydrate ratio was low.

"IRS1 variants are associated with insulin resistance and related traits and are modulated by diet in two populations of different ancestries," Zheng and colleagues conclude.

Explore further: Insulin receptor substrate 1 variant linked to GFR

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Insulin receptor substrate 1 variant linked to GFR

June 1, 2012

(HealthDay) -- A variant of the human insulin receptor substrate 1 (IRS1) gene, which plays an important role in modulating tissue response to insulin, is significantly associated with glomerular filtration rate (GFR), according ...

Amino acid levels linked to type 2 diabetes risk

May 9, 2012

(HealthDay) -- Levels of some amino acids are associated with glycemia and insulin resistance and predict the development of type 2 diabetes in men, according to a study published online May 2 in Diabetes.

Genetic variant is linked to obesity and insulin resistance

June 26, 2012

A large study in people at risk of diabetes has found a direct association between the presence of a small genetic alteration in a hormone receptor and increased body fat and insulin resistance. The results, to be presented ...

Recommended for you

Unique molecular atlas of pancreas produced

September 23, 2016

Researchers at Karolinska Institutet have managed to produce the first molecular map of the genes that are active in the various cells of the human pancreas. They have also revealed differences in genetic activity between ...

Can long naps cause diabetes?

September 14, 2016

A study presented at a scientific congress Thursday reported a link between long naps and a higher risk of diabetes, though it couldn't say if daytime sleeping was a symptom or a cause.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.