Intensive glucose control improves CVD risk factors

Intensive glucose control improves CVD risk factors
Intensive glucose-lowering therapy is associated with favorable changes in lipoprotein levels and inflammatory risk factors even though it does not lower the incidence of cardiovascular events, according to a study published online March 27 in Diabetes Care.

(HealthDay)—Intensive glucose-lowering therapy (INT) is associated with favorable changes in lipoprotein levels and inflammatory risk factors even though it does not lower the incidence of cardiovascular events, according to a study published online March 27 in Diabetes Care.

Juraj Koska, M.D., from the Phoenix Veterans Affairs Health Care System, and colleagues analyzed standard plasma lipids, cholesterol content of lipoprotein subfractions, and plasma inflammatory and prothrombotic markers in 266 participants of the Veterans Affairs Diabetes Trial. Measurements were taken at baseline and following nine months of either INT or standard therapy.

The researchers found that INT significantly lowered glycated hemoglobin compared to standard treatment (median reduction 2 percent versus 0.7 percent, respectively). INT also significantly increased BMI (4 versus 1 percent), total HDL (9 versus 4 percent), HDL2 (14 versus 0 percent), LDL2 (36 versus 1 percent), and plasma adiponectin (130 versus 80 percent). There were also significant reductions in triglycerides (213 versus 24 percent) and small, dense LDL4 (239 versus 213 percent). INT had no effect on levels of plasma apolipoproteins B-100 and B-48, C-reactive protein, interleukin-6, lipoprotein-associated phospholipase A2, myeloperoxidase, , and plasminogen activator inhibitor 1. Baseline interleukin-6 (hazard ratio per each quartile increase, 1.33), total LDL (1.25), apolipoprotein B-100 (1.29), and fibrinogen (1.26) were associated with incident macrovascular events but not changes in any at 9 months

"INT was associated with improved adiponectin, , and a favorable shift in LDL and HDL subfractions after nine months," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Clopidogrel after MI less effective in diabetes patients

date Sep 05, 2012

(HealthDay)—Clopidogrel therapy following a heart attack does less to reduce the risk of death in patients with diabetes than in those without diabetes, according to a study published in the Sept. 5 issue ...

Exercise stimulates adiponectin, raises HDL levels

date Oct 18, 2012

(HealthDay)—Intensive lifestyle intervention for weight loss (ILI) significantly improves high-density lipoprotein cholesterol (HDL-C) levels in overweight and obese individuals with type 2 diabetes, which ...

Peer coaching model beneficial for patients with diabetes

date Apr 03, 2013

(HealthDay)—Health coaching by peers is associated with a significant reduction in hemoglobin A1c (HbA1c) levels among patients treated in public health clinics, according to research published in the March/April ...

Recommended for you

Faster heart rate linked to diabetes risk

date 5 hours ago

An association between resting heart rate and diabetes suggests that heart rate measures could identify individuals with a higher future risk of diabetes, according to an international team of researchers.

EBV co-infection may boost malaria mortality in childhood

date 20 hours ago

Many people who live in sub-Saharan Africa develop a natural immunity to malaria, through repeated exposure to Plasmodium parasites. Even so, the disease kills close to half a million children per year, according ...

Three important things you didn't know about diabetes

date May 21, 2015

When we think of diabetes, we tend to think of rich people with poor lifestyles. A chronic disease linked with obesity, heart disease and worse outcomes for some infectious diseases, diabetes tends to be ...

Changes observed in HbA1c during ramadan

date May 20, 2015

(HealthDay)—For patients with type 2 diabetes, during Ramadan, the greatest change among metabolic parameters is seen for glycemia, according to a study published online May 13 in the Journal of Diabetes In ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.