Laser optics plus ultrasound imaging holds promise as a noninvasive test for prostate cancer

Multispectral photoacoustic imaging, which combines laser optics and ultrasound imaging technologies, can reliably distinguish between benign and malignant prostate tissue, a new study indicates.

Researchers at the University of Rochester looked at 42 prostatectomy specimens using the new imaging technique. Multispectral photoacoustic imaging, still in its infancy, predicted 25 out of 26 benign tissues correctly and 13 out of 16 malignant tissues correctly, said Dr. Vikram Dogra, lead author of the study.

Lipids, water, oxyhemoglobin and deoxyhemoglobin in the blood all respond to laser light, said Dr. Dogra. "By observing increases and decreases in these four things, we can tell if the tissue is malignant or benign, he said. "Deoxyhemoglobin is the biggest distinguisher between malignant and benign. If deoxyhemoglobin increases even slightly in intensity, the odds that the tissue is malignant increases dramatically," he said.

Prostate cancer is the second leading cause of in American men. Transrectal ultrasound, the current gold standard to diagnose prostate cancer, has an overall success rate of about 70%, said Dr. Dogra. "Transrectal ultrasound is an and most men do not like it. There is a need for a new imaging technique," Dr. Dogra said. "We expect this technique to be clinically available in about five years," he added.

Dr. Dogra will present his study at the ARRS annual meeting on April 18 in Washington, DC.

Related Stories

Elastography helps identify patients who need biopsy

date Jan 12, 2011

A new ultrasound technique is proving valuable in distinguishing malignant from benign breast lesions in some patients – results that could mean fewer unnecessary breast biopsies, a new study shows.

Ultrasound may better classify ovarian tumors

date Nov 13, 2007

An elevated level of the protein CA-125 in blood is considered an indicator of whether an ovarian tumor is benign or malignant. This measure, however, can often be inaccurate. Another option is an ultrasound examination of ...

Recommended for you

Study finds new potential melanoma drug target

date May 02, 2015

A new treatment for melanoma could be on the horizon, thanks to a finding by a UNC Lineberger Comprehensive Cancer Center-led team. In the study, which was published online today in the journal Clinical Ca ...

Surgery for terminal cancer patients still common

date May 02, 2015

The number of surgeries performed on terminally ill cancer patients has not dropped in recent years, despite more attention to the importance of less invasive care for these patients to relieve symptoms and ...

Study provides comprehensive look at brain cancer treatments

date May 01, 2015

Led by the Translational Genomics Research Institute (TGen) and UC San Francisco (UCSF), a comprehensive genetic review of treatment strategies for glioblastoma brain tumors was published today in the Oxford University Press ...

How artificial tanning can lead to melanoma

date May 01, 2015

Young women may be up on the latest fashions and trends as they prepare for prom season. But what many don't know is that the tan that looks oh-so-good with their dress may be the first step toward skin cancer.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.