Mortality predictors in CV implantable device infection ID'd

April 4, 2013
Mortality predictors in CV implantable device infection ID'd
Infective endocarditis related to a cardiovascular implantable electronic device, corticosteroid therapy, and other comorbidities are tied to reduced short- and long-term survival, according to a study published in The American Journal of Cardiology.

(HealthDay)—Infective endocarditis related to a cardiovascular implantable electronic device (CIED), corticosteroid therapy, and other comorbidities are tied to reduced short- and long-term survival, according to a study published in The American Journal of Cardiology.

Ammar Habib, M.D., from the Mayo Clinic in Rochester, Minn., and colleagues retrospectively reviewed 415 patients with CIED infection who were admitted to Mayo Clinic from January 1991 to December 2008. Medical records and the United States Social Security Index were used to ascertain survival data.

The researchers found that at a mean follow-up of 6.9 years, 243 patients were still alive. Heart failure (odds ratio [OR], 9.31), corticosteroid therapy (OR, 4.04), and presentation with CIED-related infective endocarditis (OR, 5.60) were associated with increased short-term mortality in a multivariate model. Long-term mortality was associated with patient age (hazard ratio [HR], 1.20), (HR, 2.01), metastatic malignancy (HR, 5.99), corticosteroid therapy (HR, 1.97), renal failure (HR, 1.94), and CIED-related infective endocarditis (HR, 1.68) in a multivariate model.

"In conclusion, these data suggest that the development of CIED-related and the presence of comorbid conditions are associated with increased short- and long-term mortality in patients with CIED infection," the authors write.
Several authors report to the medical device industry.

Explore further: Cardiovascular IED infections have distinct features, outcomes

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Early surgery ups outcomes in infective endocarditis

June 28, 2012

(HealthDay) -- For patients with infective endocarditis and large vegetations, early surgery reduces death from any cause and embolic events, compared with conventional treatment, according to a study published in the June ...

Recommended for you

Aspirin regimen for older adults has long-term benefits

November 30, 2016

For older Americans with a high risk of heart disease, taking low-dose aspirin every day could reduce their risk of a heart attack, prevent some cancers and cancer death, extend their lives and save the lives of hundreds ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.