Nanoparticles boost therapeutic potential of siRNA drugs

©2013, Mary Ann Liebert, Inc., publishers

New classes of drugs that can silence specific genes, such as small interfering RNAs (siRNAs), offer great therapeutic potential. But the specific delivery of siRNAs to target cells to exert their effects remains a significant challenge. A novel nanoparticle-based approach that enables more efficient delivery of siRNA drugs is presented in Nucleic Acid Therapeutics.

Compared to a commonly used -based transport agent, the cSCK nanoparticles described in this article better protected siRNAs from being degraded in the and were associated with greater gene silencing efficiency of siRNA drugs.

The study authors, Yuefei Shen, Huafeng Fang, Ke Zhang, and John-Stephen Taylor, Washington University, St. Louis, MO, and Ritu Shrestha and Karen Wooley, Texas A&M University, College Station, TX, attribute the better gene silencing efficiency achieved with cSCKs with improved cell uptake of the siRNAs. They present their findings in the article "Effective Protection and Transfection of siRNA by Cationic Shell-Crosslinked Knedel-Like Nanoparticles (cSCKs)." (http://online.liebertpub.com/doi/full/10.1089/nat.2012.0390)

"The potential of siRNAs as therapeutic agents is immense, but we still have to develop better and more targeted delivery methods for many diseases," says Executive Editor Fintan Steele, PhD, SomaLogic, Inc., Boulder, CO. "The work of Shen and colleagues demonstrates that nanotechnology approaches are rapidly progressing towards the goal of meeting the challenge of delivery."

More information: The article is available on the Nucleic Acid Therapeutics website (http://www.liebertpub.com/nat).

Related Stories

Pack 'Em In -- Gold Nanoparticles Improve Gene Regulation

date Feb 23, 2009

Investigators at Northwestern University have found that packing small interfering RNA (siRNA) molecules onto the surface of a gold nanoparticle can protect siRNAs from degradation and increase their ability to regulate genes ...

Recommended for you

Bacteria play only a minor role stomach ulcers in cattle

date Apr 17, 2015

Scientists at the University of Veterinary Medicine Vienna investigated whether stomach ulcers in cattle are related to the presence of certain bacteria. For their study, they analysed bacteria present in ...

New research reveals how our skeleton is a lot like our brain

date Apr 17, 2015

Researchers from Monash University and St Vincent's Institute of Medical Research in Melbourne have used mathematical modelling combined with advanced imaging technology to calculate, for the first time, the number and connectivity ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.