Python venom traces could waste antivenom

A University of Queensland researcher has found the potential for Australian doctors to prescribe expensive antivenom to snake bite victims who don't need it.

UQ School of Biological Sciences Associate Professor Bryan Grieg Fry and colleagues have published research this week which shows are a surprising potential source of false-positives in detection kits.

Associate Professor Fry said that although pythons were non-venomous, "relic" traces of venom in their could trigger the extremely sensitive snake venom detection kits.

"Using antivenom to treat patients with python bite injuries could potentially trigger life-threatening allergies to the antivenom, without the benefit of curing a snake bite," he said.

"Unnecessary use of the antivenom reduces stocks available for patients who actually need it."

Associate Professor Fry said this highlighted the decisions about administering antivenom should be based on the severity of clinical symptoms.

"A venom detection kit should be used to ensure that the appropriate is given, but it is sometimes mistakenly used as a diagnosis of by itself," he said.

"All snakes evolved from a that was a venomous lizard."

"Evolution is like a crime scene, there is always evidence to be found if the scientist is a good enough detective."

Associate Professor Fry said snakes had varying potency of 'venomosity' ranging from those capable of life-threatening bites, such as or taipans, to those that have lost almost all their venom, such as egg-eating and pythons.

Previous studies that found python saliva could cross-react in the snake venom detection kit were dismissed as an anomaly.

Associate Professor Fry's study found that a python's oral glands predominantly secrete mucous to aid in swallowing large prey, but there are also traces of relic venom.

"The extremely low levels of toxins in their mouths have no effect on prey or bitten humans, however in forensic-level diagnostic tools like the snake venom detection kit, they cross-react and give a false positive."

"These novel molecules represent an untapped resource for biodiscovery," Associate Professor Fry said.

"We have found that the low level of ancient toxins still secreted in these glands includes novel compounds quite different than those from their well-studied cousins like rattlesnakes or mambas."

"In addition to providing insights regarding how the snake venom system evolved, these results reinforce the value of studying a wide range of snakes, as novel compounds with significant potential for use in drug design and development may be uncovered in the most unlikely of places," he said.

The study findings are published in Molecular & Cellular Proteomics.

add to favorites email to friend print save as pdf

Related Stories

Deadly sea snake has a doppelganger

Nov 19, 2012

(Phys.org)—Scientists have discovered that the lethal beaked sea snake is actually two species with separate evolutions, which resulted in identical snakes.

New species of sea snake discovered

Feb 21, 2012

(PhysOrg.com) -- Scientists have discovered a new species of sea snake in the Gulf of Carpenteria, northern Australia, which is unique in having raised scales.

Recommended for you

ALS Ice Bucket Challenge arrives in North Korea

18 hours ago

It's pretty hard to find a novel way to do the ALS Ice Bucket Challenge by now, but two-time Grammy-winning rapper Pras Michel, a founding member of the Fugees, has done it—getting his dousing in the center ...

Cold cash just keeps washing in from ALS challenge

Aug 28, 2014

In the couple of hours it took an official from the ALS Association to return a reporter's call for comment, the group's ubiquitous "ice bucket challenge" had brought in a few million more dollars.

Medtronic spends $350M on another European deal

Aug 27, 2014

U.S. medical device maker Medtronic is building stronger ties to Europe, a couple months after announcing a $42.9 billion acquisition that involves moving its main executive offices across the Atlantic, where it can get a ...

User comments