Teens targeting strength, cardio fitness battle insulin resistance

April 25, 2013
Teens targeting strength, cardio fitness battle insulin resistance
Lower levels of abdominal muscle strength and cardiorespiratory fitness in youth are independently associated with adverse levels of fasting insulin, insulin sensitivity, and β-cell function in young adulthood, according to a study published online April 11 in Diabetes Care.

(HealthDay)—Lower levels of abdominal muscle strength and cardiorespiratory fitness (CRF) in youth are independently associated with adverse levels of fasting insulin, insulin sensitivity, and β-cell function in young adulthood, according to a study published online April 11 in Diabetes Care.

Anders Grøntved, M.P.H., from the University of Southern Denmark in Odense, and colleagues analyzed data from 317 youth prospectively followed for 12 years. The participants had measurements taken in youth for maximal voluntary contractions during isometric back extension and abdominal flexion using a strain-gauge dynamometer, while CRF was obtained from a maximal cycle ergometer test. Additionally, fasting serum insulin and glucose were measured during youth and in young adulthood.

The researchers found that for each one standard deviation difference in isometric muscle strength (0.16 N/kg) in youth, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), and HOMA of β-cell function (HOMA-B) in young adulthood changed by −11.3, −12.2, and −8.9 percent, respectively, in . These findings were after adjusting for CRF, personal lifestyle, and demographic factors. Results were consistent even with additional adjustment for general or abdominal adiposity in youth. There was an additive combined association between muscle strength and CRF with fasting insulin, HOMA-IR, and HOMA-B. Adolescents in the highest sex-specific tertile for both isometric muscle strength and CRF had the lowest levels of these outcomes.

"Increasing muscle strength and CRF should be targets in youth primordial prevention strategies of and β-cell dysfunction," the authors write.

Explore further: Insulin resistance may be associated with stroke risk

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Insulin resistance may be associated with stroke risk

October 11, 2010

Insulin resistance, a condition in which insulin produced by the body becomes less effective in reducing blood glucose levels, appears to be associated with an increased risk of stroke in individuals without diabetes, according ...

Insulin resistance increases risk of colorectal adenomas

March 27, 2012

(HealthDay) -- Insulin resistance (IR) and central obesity, as measured by waist to hip ratio (WHR), are associated with a significantly increased risk of colorectal adenomas, especially in men, according to a study published ...

Metabolites linked to insulin resistance in normoglycemia

April 23, 2012

(HealthDay) -- Twenty metabolites, including amino acids, intermediates in glucose synthesis, ketone bodies, and fatty acids, are associated with insulin resistance, according to a study published online April 17 in Diabetes.

Metformin may have dual effect in breast cancer

May 9, 2012

(HealthDay) -- For women without diabetes and with operable breast cancer, administration of metformin prior to surgery does not significantly affect the proliferative marker Ki-67 overall, but drug effects are observed according ...

Hyperinsulinemia in early adulthood tied to later HTN

June 28, 2012

(HealthDay) -- Young adults with hyperinsulinemia are significantly more likely to have hypertension (HTN) later in life, regardless of sex, ethnicity, or body weight, according to a study published in the July issue of Diabetes ...

Low insulin secretion tied to depressive symptoms in women

December 29, 2012

(HealthDay)—Middle-aged women with insulin secretion levels in the lowest quintile appear to have more than twice the risk of developing new-onset depressive symptoms compared with those with higher insulin secretion levels, ...

Recommended for you

New study reveals a novel protein linked to type 2 diabetes

August 16, 2016

Findings from Boston University School of Medicine (BUSM), which appear in eLife, provide a possible explanation as to why most people who are obese develop insulin resistance and type 2 diabetes. A minority of obese individuals, ...

Gene variant explains differences in diabetes drug response

August 9, 2016

The first results from a large international study of patients taking metformin, the world's most commonly used type 2 diabetes drug, reveal genetic differences among patients that may explain why some respond much better ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.