Topical treatment effective for toenail fungal infection

Topical treatment effective for toenail fungal infection
Once daily topical efinaconazole is effective in treating fungal infections of the toenail, according to a study published in the April issue of the Journal of the American Academy of Dermatology.

(HealthDay)—Once daily topical efinaconazole is effective in treating fungal infections of the toenail, according to a study published in the April issue of the Journal of the American Academy of Dermatology.

As part of two studies, Boni E. Elewski, M.D., from the University of Alabama at Birmingham School of Medicine, and colleagues randomized 870 patients (first study) and 785 patients (second study) with toenail distal lateral subungual onychomycosis in a 3:1 ratio to efinaconazole (10 percent solution) or vehicle once a day for 48 weeks. Participants were followed up at four weeks post-treatment.

At week 52, the researchers found that the mycologic cure rate was significantly higher for patients treated with efinaconazole (55.2 versus 16.8 percent for study 1; 53.4 versus 16.9 percent for study 2). The complete cure rate (defined as no clinical involvement of the target toenail, negative examination, and negative fungal culture) was also significantly higher in the efinaconazole group (17.8 versus 3.3 percent for study 1; 15.2 versus 5.5 percent for study 2). (< 10 percent clinical involvement) was also achieved in significantly more patients treated with efinaconazole (35.7 versus 11.7 percent for study 1; 31.0 versus 11.9 percent for study 2). The rate of adverse events was similar for the efinaconazole and vehicle groups, according to the study.

"Once daily topical efinaconazole appears to be a viable alternative to oral treatment options for onychomycosis," Elewski and colleagues conclude.

The study was funded by Valeant Pharmaceuticals North America LLC, which manufactures efinaconazole. Several authors are employees of and/or disclosed with pharmaceutical companies, including Valeant.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Vitreolytic ocriplasmin resolves vitreomacular traction

Aug 16, 2012

(HealthDay) -- Intravitreal injection of the vitreolytic agent ocriplasmin resolves vitreomacular traction and closes macular holes significantly better than placebo, but with a higher incidence of adverse ...

Clopidogrel after MI less effective in diabetes patients

Sep 05, 2012

(HealthDay)—Clopidogrel therapy following a heart attack does less to reduce the risk of death in patients with diabetes than in those without diabetes, according to a study published in the Sept. 5 issue ...

Recommended for you

WHO: Ebola vaccine trials in W. Africa in January

7 hours ago

Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe, a top World Health Organization official ...

Ebola cases rise sharply in western Sierra Leone

8 hours ago

After emerging months ago in eastern Sierra Leone, Ebola is now hitting the western edges of the country where the capital is located with dozens of people falling sick each day, the government said Tuesday. So many people ...

User comments

Adjust slider to filter visible comments by rank

Display comments: newest first

cyberCMDR
not rated yet Apr 12, 2013
Another effective treatment (in my experience). Shower everyday, but with this routine: First get yourself thoroughly wet by running the shower a minute or two. Next, apply some Selsun Blue shampoo to the affected area. Rinse your hands, then lather up the rest of your body with regular soap. Shampoo, with your hair still wet from the original wetting. Then turn the water back on to rinse your body and to clean your face. The period while lathering up allows the Selsun Blue to sink into the skin and nails. Keep this up, and the nails will grow out clean over a couple of months.