ASC: Rapid BP lowering tx no better for intracerebral bleed

May 29, 2013
ASC: rapid BP lowering tx no better for intracerebral bleed
For patients with spontaneous intracerebral hemorrhage and elevated systolic blood pressure, intensive, rapid blood pressure lowering treatment is not associated with a significant reduction in death or severe disability at 90 days compared with guideline-recommended treatment, according to a study published online May 29 in the New England Journal of Medicine to coincide with presentation at the annual European Stroke Conference, held from May 28 to 31 in London.

(HealthDay)—For patients with spontaneous intracerebral hemorrhage and elevated systolic blood pressure, intensive, rapid blood pressure lowering treatment is not associated with a significant reduction in death or severe disability at 90 days compared with guideline-recommended treatment, according to a study published online May 29 in the New England Journal of Medicine to coincide with presentation at the annual European Stroke Conference, held from May 28 to 31 in London.

Craig S. Anderson, M.D., Ph.D., from the George Institute for Global Health at the University of Sydney, and colleagues randomized 2,794 patients with spontaneous intracerebral hemorrhage within the previous six hours, who had elevated systolic blood pressure, to receive intensive blood pressure lowering treatment or guideline-recommended treatment.

The researchers found that the primary outcome of death or major disability at 90 days occurred in 52 percent of those receiving , compared with 55.6 percent of those receiving guideline-recommended treatment (odds ratio with intensive treatment, 0.87; P = 0.06). Significantly lower modified Rankin scores were seen with intensive treatment on ordinal analysis (odds ratio for greater disability, 0.87; P = 0.04). Mortality was 11.9 and 12 percent, respectively, in the intensive treatment and guideline-recommended treatment groups. Nonfatal occurred in 23.3 percent of the intensive treatment group and in 23.6 percent of the guideline-recommended treatment group.

"In patients with intracerebral hemorrhage, intensive lowering of blood pressure did not result in a significant reduction in the rate of the primary outcome of death or severe disability," the authors write.

Several authors disclosed to the pharmaceutical industry.

More information: Abstract
Full Text
Editorial
More Information

Related Stories

ASH: More intense treatment beneficial in polycythemia vera

December 10, 2012

(HealthDay)—For patients with polycythemia vera, more intense treatment to achieve a hematocrit target of less than 45 percent correlates with a significantly lower rate of cardiovascular death and major thrombosis compared ...

ATS: Early prone positioning reduces mortality in ARDS

May 21, 2013

(HealthDay)—For patients with acute respiratory distress syndrome (ARDS), prolonged prone positioning during mechanical ventilation is associated with significantly reduced mortality at 28 and 90 days, according to a study ...

Recommended for you

Experimental MERS vaccine shows promise in animal studies

July 28, 2015

A two-step regimen of experimental vaccines against Middle East respiratory syndrome (MERS) prompted immune responses in mice and rhesus macaques, report National Institutes of Health scientists who designed the vaccines. ...

Can social isolation fuel epidemics?

July 21, 2015

Conventional wisdom has it that the more people stay within their own social groups and avoid others, the less likely it is small disease outbreaks turn into full-blown epidemics. But the conventional wisdom is wrong, according ...

Lack of knowledge on animal disease leaves humans at risk

July 20, 2015

Researchers from the University of Sydney have painted the most detailed picture to date of major infectious diseases shared between wildlife and livestock, and found a huge gap in knowledge about diseases which could spread ...

IBD genetically similar in Europeans and non-Europeans

July 20, 2015

The first genetic study of inflammatory bowel disease (IBD) to include individuals from diverse populations has shown that the regions of the genome underlying the disease are consistent around the world. This study, conducted ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.