Genetic variant may explain weight loss post-RYGB surgery

May 7, 2013
Genetic variant may explain weight loss post-RYGB surgery
A genetic variant associated with weight loss after Roux-en-Y gastric bypass surgery has been identified, according to a study published in the May 2 issue of the American Journal of Human Genetics.

(HealthDay)—A genetic variant associated with weight loss after Roux-en-Y gastric bypass (RYGB) surgery has been identified, according to a study published in the May 2 issue of the American Journal of Human Genetics.

Ida J. Hatoum, Sc.D., from Massachusetts General Hospital in Boston, and colleagues performed a genome-wide association study involving 693 individuals undergoing RYGB to examine potential genetic factors associated with weight loss. Findings were replicated in an independent population of 327 individuals undergoing RYGB.

The researchers found that there was a significant correlation between a 15q26.1 locus near ST8SIA2 and SLCO3A1 and weight loss after RYGB. Baseline ST8SIA2 expression in omental fat of these individuals correlated significantly with post-RYGB weight loss. In addition, expression of St8sia2 and Slco3a1 was significantly altered in metabolically active tissues in RYGB-treated versus weight-matched sham-operated mice.

"We have identified a that is reproducibly associated with weight loss after RYGB," the authors write. "This study provides evidence for the use of genomics to identify response to surgical procedures (surgicogenomics)."

Several authors disclosed to Merck, which partially funded the study.

Explore further: Gastric bypass surgery alters gut microbiota profile along the intestine

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Calorie reduction, not bypass surgery, ups diabetes control

April 11, 2013

(HealthDay)—Calorie reduction rather than the actual Roux-en-Y gastric bypass (RYGB) surgery seems to account for the improvement in glucose homeostasis in obese patients with type 2 diabetes who undergo RYGB, according ...

Recommended for you

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.