Germ-fighting vaccine system makes great strides in delivery

A novel vaccine study from South Dakota State University (SDSU) will headline the groundbreaking research that will be unveiled at the American Association of Pharmaceutical Scientists' (AAPS) National Biotechnology Conference (NBC). The meeting takes place Monday, May 20 - Wednesday, May 22 at the Sheraton San Diego Hotel and Marina.

"The main goal of a is to stimulate the immune system to fight against a pathogen that causes the disease", explained Dr. Hemachand Tummala, assistant professor of Pharmaceutical Sciences at SDSU. "We want to make a delivery system that mimics pathogens in stimulating the immune system but not cause infection."

Tummala and his doctoral student, Sunny Kumar, used inulin acetate taken from a fiber derived from tubers, such as dahlias or chicory. "The fiber is natural, inexpensive and easily accessible", Tummala stated. "Most importantly, it acts as a PAMP [pathogen-associated molecular pattern]. We made pathogen-like nanoparticles with inulin acetate and incorporated pathogen-related antigens inside them." Tummala explained, "Once the sense these particles as pathogens, they eat them and process them as PAMPs." This then aggravates the immune system.

The researchers then tested the technology in preventing a . Tummala collaborated with Dr. Victor Huber, assistant professor and infectious disease specialist at the Sanford School of Medicine, whose research focuses on influenza.

The researchers then tested the efficiency of the system in mice against a lethal challenge of the 2009 pandemic H1N1 . One group of mice was not immunized, while the others received a vaccine containing one or two antigens. Within eight days, 90 percent of the unvaccinated mice died. Those who received one antigen contracted the flu, and all but one recuperated. None of those who received the vaccine with two antigens acquired the flu.

"The low cost of the technology, estimated at one or two dollars per dose, also makes it suitable for animal vaccines," Tummala explained. He is working with other SDSU researchers to apply the delivery to sheep and swine vaccines.

Dr. Tummala and his team will also receive the 2013 American Association of Pharmaceutical Scientists Innovation in Biotechnology Award for their research on Tuesday, May 21.

add to favorites email to friend print save as pdf

Related Stories

Way to make one-way flu vaccine discovered

Dec 18, 2012

A new process to make a one-time, universal influenza vaccine has been discovered by a researcher at Georgia State University's Center for Inflammation, Immunity and Infection and his partners.

Researchers develop mRNA based flu vaccine

Nov 26, 2012

(Phys.org)—A joint research effort by the Friedrich-Loeffler-Institute and pharmaceutical company CureVac, both based in Germany, has resulted in the creation of a new type of flu vaccine. The vaccine, as the team describes ...

Recommended for you

Scientists image a beating heart in 3D (w/ Video)

1 hour ago

Researchers of the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden report how they managed to capture detailed three-dimensional images of cardiac dynamics in zebrafish. The novel approach: ...

New device to monitor lung function in space

1 hour ago

A new method of collecting blood from the ear, currently part of an interactive exhibition at the Science Museum, could be used to monitor lung function in space. Less invasive, faster and more accurate than current methods, ...

Primate research center plays key role in HIV study in Nature

1 hour ago

In a study reported in Nature this month, Yerkes National Primate Research Center researchers were key in determining that treating SIV-infected rhesus macaques with type 1 interferon, a protein known to trigger antiviral respon ...

Three-people IVF debate process on the move in UK

4 hours ago

Takes two to make a child, correct? No. maybe. The use of sperm and eggs from three people to create babies moved a step closer in the UK, with Tuesday's events. What kind of egg-sperm distribution are we talking about? The ...

User comments