Lab charts age-related changes in Alzheimer's mice

Scientists at the University of Kentucky recently performed a comprehensive characterization of age-related behavioral changes in an important mouse model of Alzheimer's disease.

Led by Linda Van Eldik, director of UK's Sanders-Brown Center on Aging, the researchers examined , anxiety-like behavior and cognitive ability at different stages in the lifespan of the mice: young (7 months), middle-aged (11 and 15 months), and old (24 months).

The study found no impairments in motor function or anxiety-like behavior in the mice at any age tested. However, the mice developed Alzheimer-like as they aged.

The report, titled "Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease," was published in the journal Alzheimer's Research & Therapy, with co-authors Scott Webster and Adam Bachstetter from the Van Eldik lab. This is the first study to provide such an in-depth characterization of this Alzheimer's mouse model.

The study used the new, state-of-the-art University of Kentucky Rodent Behavior Core, directed by Bruce O'Hara, for many of the behavioral experiments.

"It's wonderful to have a resource like the RBC available here at UK," Webster said. "It provides a vital step in translating our basic scientific findings into future clinical applications."

The Van Eldik lab anticipates that this report will provide a valuable resource to aid Alzheimer drug discovery, by providing a detailed behavioral characterization of this , and comparing it to other Alzheimer mouse models.

Related Stories

p38beta MAPK not critical to brain inflammation, study finds

date Feb 19, 2013

(Medical Xpress)—A study by a leading Alzheimer's researcher at the University of Kentucky provides new evidence that will help researchers home in on the molecular mechanisms involved in inflammation of the central nervous ...

Research sheds new light on traumatic brain injuries

date Apr 15, 2013

Even a mild injury to the brain can have long lasting consequences, including increased risk of cognitive impairment later in life. While it is not yet known how brain injury increases risk for dementia, there are indications ...

Innovative method to treat Alzheimer's in mice

date Apr 01, 2013

Researchers from the RIKEN Brain Science Institute report that they successfully used a virus vector to restore the expression of a brain protein and improve cognitive functions, in a mouse model of Alzheimer's ...

Recommended for you

New approaches for early diagnosis of Alzheimer's

date 18 hours ago

Mild cognitive impairment, or MCI, may be one of Alzheimer's earliest signs. The subtle changes of MCI include problems with memory, language, thinking and judgment and a subjective sense that mental function ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.