Study shows premature birth interrupts vital brain development processes leading to reduced cognitive abilities

May 20, 2013

Researchers from King's College London have for the first time used a novel form of MRI to identify crucial developmental processes in the brain that are vulnerable to the effects of premature birth. This new study, published today in the Proceedings of the National Academy of Sciences (PNAS), shows that disruption of these specific processes can have an impact on cognitive function.

The researchers say the new techniques developed here will enable them to explore how the disruption of key processes can also cause conditions such as autism, and will be used in future studies to test possible treatments to prevent .

The study was funded by: the Medical Research Council; the Engineering and Physical Sciences Research Council; the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy's and St Thomas' NHS Foundation trust and King's College London; and the NIHR Biomedical Research Centre at Imperial College London. Infants involved in the study were being cared for in the Unit at Queen Charlotte's and Chelsea Hospital.

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This video shows the development of the frontal and temporal regions of the cerebral cortex in preterm infants during the last three months before the normal time of birth, turning from red to blue as it matures. The primary motor and sensory regions are well developed at the beginning of the sequence, while much of the association cortex involved in complex functions develop rapidly over this period, particularly in the most frontal regions. Despite this rapid maturation, premature babies are less developed at term than infants born at the normal time. Credit: King's College London

Scientists from King's College London and Imperial College London used diffusion MRI – a type of imaging which looks at the natural diffusion of water – to observe the maturation of the cerebral cortex where much of the brain's computing power resides. By analysing the diffusion of water in the cerebral cortex of 55 premature infants and 10 babies born at full term they mapped the growing complexity and density of across the whole of the cortex in the months before the normal time of birth.

They found that during this period maturation was most rapid in areas of the brain relating to social and emotional processing, decision making, and visual-spatial processing. These functions are often impaired after premature birth, and the researchers found that was reduced in preterm compared to full term infants, with the greatest effect in the most premature infants. When they re-examined the infants at two years of age, the preterm infants with the slowest cortical development performed less well on neurodevelopmental testing, demonstrating the longer-term impact of prematurity on cortical maturation.

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This video shows the development of the occipital and parietal regions of the cerebral cortex in preterm infants during the last three months before the normal time of birth, turning from red to blue as it matures. The occipital cortex associated with visual function is most developed at the beginning of the sequence, while the association cortex in the parietal lobes develops rapidly over this period. Despite this rapid maturation, premature babies are less developed at term than infants born at the normal time. Credit: King's College London

Professor David Edwards, Director of the Centre for the Developing Brain at King's College London, based at the Evelina Children's Hospital, said: 'The number of babies born prematurely is increasing, so it has never been more important to improve our understanding of how preterm birth affects brain development and causes brain damage. We know that prematurity is extremely stressful for an infant, but by using a new technique we are able to track brain maturation in babies to pinpoint the exact processes that might be affected by premature birth. Here we have used innovative ways to understand how the development of the is affected.

'These findings highlight a key stage of brain development where the neurons branch out to create a complex, mature structure. We can now see that this happens in the latter stages of development that would usually take place in healthy babies when they are still in the womb. This suggests that premature birth can interrupt this vital developmental process. It may explain why we sometimes see adverse effects on brain development in those born only slightly prematurely as we now know that this process is happening right up to the normal time of birth. With this study we found that the earlier a baby is born, the less mature the cortex structure. The weeks a baby loses in the womb really matter.

'These new techniques we've developed to identify these crucial processes will allow us to examine how disruption caused by can lead to conditions such as autism and learning difficulties. We will also use the technique in future studies to test new treatments to prevent damage. It's an extremely exciting step forward.'

More information: Development of cortical microstructure in the preterm human brain, www.pnas.org/cgi/doi/10.1073/pnas.1301652110

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