Sleep apnea and pre-eclampsia share a common warning sign

June 27, 2013
Sleep apnea and pre-eclampsia share a common warning sign
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Many, but not all, people with sleep apnea develop high blood pressure. In a new study, Yale researchers show those who develop hypertension have many similarities with pregnant woman with pre-eclampsia.

The findings could shed light on individual risk associated with , which is associated with increased risk of heart disease and stroke. At least 15 percent of adults suffer from the condition, which is marked by a cessation of breathing during sleep.

"You wouldn't imagine that a 50-year-old obese man would have so much in common with a 30-year-old pregnant woman but they do," said Dr. Vahid Mohsenin of the Yale Center for Sleep Medicine and senior author of the study in the Journal of Cardiovascular Disease Research.

Mohensin and co-author Dr. Behrouz Jafari of the University of California-Irvine found subjects with sleep apnea and hypertension had damage to cells lining blood vessels, whether or not were lowered. Those with hypertension also had elevated levels of soluble endoglin in their blood, which are known to cause hypertension in women with pre-eclampsia.

Endoglin is already used as a marker of placental malformation and development of pre-eclampsia, a potentially dangerous condition marked sudden onset of during pregnancy. The current study demonstrates that elevated circulating endoglin is also a marker of hypertension and heart disease in patients with obstructive sleep apnea.

Explore further: Study links obstructive sleep apnea to blood vessel abnormalities

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Tom_Hennessy
not rated yet Jun 27, 2013
Apnea is accompanied by erythrocytosis / increased hemoglobin and hypertension. Preeclampsia is accompanied by erythrocytosis / increased hemoglobin and hypertension. Erythrocytosis is treated by iron reduction therapy / phlebotomy. Hypertension is treated by iron reduction therapy / phlebotomy.
Is the apnea , preeclampsia and hypertension caused by increased iron levels which cause increased red blood cell production / erythrocytosis?

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