Blood tests as good as biopsy for HCV-related disease

June 4, 2013
Blood tests as good as biopsy for HCV-related disease
Compared to a liver biopsy, available blood tests are accurate for diagnosing fibrosis and cirrhosis in patients with hepatitis C virus (HCV), according to a review published in the June 4 issue of the Annals of Internal Medicine.

(HealthDay)—Compared to a liver biopsy, available blood tests are accurate for diagnosing fibrosis and cirrhosis in patients with hepatitis C virus (HCV), according to a review published in the June 4 issue of the Annals of Internal Medicine.

Roger Chou, M.D., and Ngoc Wasson, M.P.H., from the Oregon Health & Science University in Portland, conducted a literature review to identify 172 studies that compared the diagnostic accuracy of blood tests with that of .

The researchers found that the platelet count, age-platelet index, aspartate aminotransferase-platelet ratio index (APRI), FibroIndex, FibroTest, and Forns index had median positive likelihood ratios of 5 to 10 at commonly used cut-offs and areas under the receiver-operating characteristic curve (AUROCs) of 0.70 or greater for identifying clinically significant fibrosis. For determining cirrhosis, the platelet count, age-platelet index, APRI, and Hepascore had median positive likelihood ratios of 5 to 10 and AUROCs of 0.80 or greater, while the Goteborg University Cirrhosis Index and the Lok index had slightly lower positive likelihood ratios (4.8 and 4.4, respectively). There was a slightly lower AUROC with APRI than with the FibroTest for identifying fibrosis, but a substantially higher AUROC with APRI than the aspartate aminotransferase-alanine aminotransferase ratio for identifying fibrosis or cirrhosis.

"Many blood tests are moderately useful for identifying clinically significant fibrosis or cirrhosis in HCV-infected patients," the authors write.

More information: Full Text (subscription or payment may be required)

Related Stories

HIV-HCV coinfection speeds HCV-related liver fibrosis

February 27, 2013

(HealthDay)—Individuals who are coinfected with HIV and hepatitis C virus (HCV) exhibit liver fibrosis similar to that of individuals without HIV who are nearly 10 years older, according to research published online Feb. ...

Recommended for you

Can social isolation fuel epidemics?

July 21, 2015

Conventional wisdom has it that the more people stay within their own social groups and avoid others, the less likely it is small disease outbreaks turn into full-blown epidemics. But the conventional wisdom is wrong, according ...

Lack of knowledge on animal disease leaves humans at risk

July 20, 2015

Researchers from the University of Sydney have painted the most detailed picture to date of major infectious diseases shared between wildlife and livestock, and found a huge gap in knowledge about diseases which could spread ...

IBD genetically similar in Europeans and non-Europeans

July 20, 2015

The first genetic study of inflammatory bowel disease (IBD) to include individuals from diverse populations has shown that the regions of the genome underlying the disease are consistent around the world. This study, conducted ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.