Blood tests as good as biopsy for HCV-related disease

Blood tests as good as biopsy for HCV-related disease
Compared to a liver biopsy, available blood tests are accurate for diagnosing fibrosis and cirrhosis in patients with hepatitis C virus (HCV), according to a review published in the June 4 issue of the Annals of Internal Medicine.

(HealthDay)—Compared to a liver biopsy, available blood tests are accurate for diagnosing fibrosis and cirrhosis in patients with hepatitis C virus (HCV), according to a review published in the June 4 issue of the Annals of Internal Medicine.

Roger Chou, M.D., and Ngoc Wasson, M.P.H., from the Oregon Health & Science University in Portland, conducted a literature review to identify 172 studies that compared the diagnostic accuracy of blood tests with that of .

The researchers found that the platelet count, age-platelet index, aspartate aminotransferase-platelet ratio index (APRI), FibroIndex, FibroTest, and Forns index had median positive likelihood ratios of 5 to 10 at commonly used cut-offs and areas under the receiver-operating characteristic curve (AUROCs) of 0.70 or greater for identifying clinically significant fibrosis. For determining cirrhosis, the platelet count, age-platelet index, APRI, and Hepascore had median positive likelihood ratios of 5 to 10 and AUROCs of 0.80 or greater, while the Goteborg University Cirrhosis Index and the Lok index had slightly lower positive likelihood ratios (4.8 and 4.4, respectively). There was a slightly lower AUROC with APRI than with the FibroTest for identifying fibrosis, but a substantially higher AUROC with APRI than the aspartate aminotransferase-alanine aminotransferase ratio for identifying fibrosis or cirrhosis.

"Many blood tests are moderately useful for identifying clinically significant fibrosis or cirrhosis in HCV-infected patients," the authors write.

More information: Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

HIV-HCV coinfection speeds HCV-related liver fibrosis

Feb 27, 2013

(HealthDay)—Individuals who are coinfected with HIV and hepatitis C virus (HCV) exhibit liver fibrosis similar to that of individuals without HIV who are nearly 10 years older, according to research published ...

Recommended for you

How the world is underestimating Ebola: WHO

1 hour ago

The Ebola epidemic tearing through western Africa is by far the deadliest known outbreak of the disease, yet the magnitude of the spread is believed to be severely underestimated.

Last Ebola-free region of Liberia falls to virus

1 hour ago

Every region of Liberia has now been hit by Ebola, officials said Friday, as the World Health Organization warned the fight against the worst-ever outbreak of the killer disease would take months.

Ebola death toll rises to 1,427: WHO

12 hours ago

The death toll from the Ebola outbreak sweeping through west African countries has risen to 1,427 out of more than 2,600 cases, the World Health Organization said Friday.

User comments