Conflict-of-interest restrictions needed to ensure strong FDA review, analysis suggests

A 2012 law that loosened conflict-of-interest restrictions for FDA advisory panels could weaken the agency's review system and could allow more drugs with safety problems to gain market approval, says a new analysis published June 7 in Science by researchers at the George Washington University School of Public Health and Health Services (SPHHS).

The 2012 removed measures put in place by an earlier law passed in 2007, according to the report by Susan F. Wood, PhD, an associate professor of at SPHHS and Jillian K. Mador, a at the GW School of Medicine & Health Sciences (SMHS). The 2007 FDA Amendments Act put caps on the number of experts with who could serve on FDA advisory panels in order to ensure an impartial review of new drugs, the authors said.

They say there is good reason to worry about the revisions in the law that now allow FDA panels to have more members who report a conflict—such as consulting fees from companies. The removal of the requirement for "caps" on advisory committee members with financial conflicts was seen as a top priority of the pharmaceutical industry during the 2012 passage of the FDA Safety and Innovation Act.

"Panels top-heavy with experts who have financial ties to industry might be more likely to dismiss or ignore scientific evidence of risks or other problems," said Wood, who is a former FDA official and the lead author on the paper. "This analysis also suggests that loosening the restrictions could lead to an appearance of conflict—and to potentially biased recommendations for approval or disapproval of a FDA regulated product."

The authors point to historical examples of cases in which loaded panels voted for drugs that were later found to have serious safety problems.

The 2012 law was passed after the drug industry complained that the conflict of interest restrictions slowed down the FDA approval process and made it hard to fill panel positions with qualified experts. But Wood and Mador looked at the evidence and concluded that there are plenty of scientists with expertise to fill these positions—without the ties to the industry.

The analysis goes on to say that the restrictions did not affect FDA's productivity in the past and there is little reason to think that reinstituting the caps would slow down the process of bringing safe new drugs to market today. The analysis also demonstrates that the caps have never been reached, so FDA had apparently been successful in identifying experts without financial conflicts.

The analysis concludes that the evidence does not support the decision to remove the caps on conflict of interest and points out that Congress will soon begin discussing reauthorization of the 2012 law which is revised every five years. The authors urge the scientific and medical community to weigh in early on those discussions in order to point out concerns—and to ensure that the Advisory Committee and review process remains strong and effective.

Wood and Mador's new analysis, "Uncapping Conflict of Interest," appears in the June 7 issue of Science.

More information: "Uncapping Conflict of Interest?," by S.F. Wood et al. Science, 2013.

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VendicarE
1 / 5 (2) Jun 06, 2013
Nothing but American filth and Corporate Corruption.

"The 2012 law was passed after the drug industry complained that the conflict of interest restrictions slowed down the FDA approval process and made it hard to fill panel positions with qualified experts."
UrpGag
not rated yet Jun 06, 2013
Paxil is the proximate cause of death of my eleven year old daughter in 1998 as evidenced by trial record. Furthermore, Paxil and tagamet are directly involved in my fugue while driving and getting into a fatal accident. the pharmaceutical giants are strongly motivated to hide dose related side effect profile information from our doctors by direct greed. we must keep these self serving corporations and their agents out of our regulatory bodies or more human beings must die. period. keep the corporations out of the federal regulatory agencies or we are in for far worse trouble than slow releases of medication.
aironeous
not rated yet Jun 07, 2013
This is corruption. If the capitalism abusing corrupt filth of big pharma and FDA had their way they would reclassify water as a drug because it cures dehydration so they can charge $50 a bottle. This is the filth of the earth betraying all of mankind next only to the filth that abuses capitalism on wall street and never goes to jail.
alfie_null
not rated yet Jun 09, 2013
Seems like medicine (pharmacology in particular) is one of those areas where companies are poorly motivated to provide the best value to their customers.

While I note that bringing a new drug to market is hideously expensive I also understand that pharma companies go on to spend vast amounts more, marketing their medications. To end users who can't even purchase the products, only pester their physicians for prescriptions. And in maintaining an army of representatives to pimp their products to physicians across the country. And, no doubt, to encourage legislators to be friendly to pharma.