Experts find epigenetic changes moderate reality distortion in schizophrenia patients

June 10, 2013

A study in Schizophrenia Bulletin is among the first to indicate epigenetic changes related to immune function in schizophrenia. DNA methylation, a process involving the addition of a methyl group to the DNA without changing its sequence, can alter gene expression.

Led by Dr. Jingyu Liu, the nine researchers analyzed and verified changes in DNA methylation patterns in people with and without schizophrenia and found significant changes in seven genes that moderate immune responses.

In the current study, the researchers found that the seven genes that were up or down regulated protect against the delusion and hallucination symptoms in . This finding suggests that methylation changes related to immune function may be one of the pathways to moderate symptoms in schizophrenia patients.

Explore further: Gene regulator in brain's executive hub tracked across lifespan

More information: The paper "Methylation Patterns in Whole Blood Correlate With Symptoms in Schizophrenia Patients" can be accessed here: www.oxfordjournals.org/page/5147/6

Related Stories

Deciphering the cellular reading system of DNA methylation

April 12, 2013

(Medical Xpress)—Scientists from the FMI identify how a family of proteins reads the methylation marks on the DNA so critical for cell development. These MBD proteins bind directly to methylation marks and inactivate the ...

Genetic risk for schizophrenia is connected to reduced IQ

May 16, 2013

The relationship between the heritable risk for schizophrenia and low intelligence (IQ) has not been clear. Schizophrenia is commonly associated with cognitive impairments that may cause functional disability. There are clues ...

Recommended for you

Genome-editing 'toolbox' targets multiple genes at once

July 26, 2016

A Yale research team has designed a system to modify, or edit, multiple genes in the genome simultaneously, while also minimizing unintended effects. The gene-editing "toolbox" provides a user-friendly solution that scientists ...

New genetic clues into motor neuron disease

July 26, 2016

Researchers at The University of Queensland have contributed to the discovery of three new genes which increase the risk of motor neuron disease (MND), opening the door for targeted treatments.

Chinese team to pioneer first human CRISPR trial

July 22, 2016

(Medical Xpress)—A team of researchers at Sichuan University's West China Hospital has announced plans to begin a clinical trial where cells modified using the CRISPR gene editing technique will be used on human beings ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.