Cross-species malaria immunity induced by chemically attenuated parasites

Malaria, a mosquito-born infectious disease, kills over 600,000 people every year. Research has focused on the development of a vaccine to prevent the disease; however, many malaria vaccines targeting parasite antigens have failed because the antigen targets are highly variable.

Based on the observation that low-density infections can induce antibody-independent immunity to different malaria strains, Michael Good and colleagues at Griffith University in Australia created a vaccine using blood-stage malaria parasites that were attenuated with a chemical agent that keeps the parasite from multiplying.

In this issue of the Journal of Clinical Investigation, they demonstrate that mice inoculated with a single species of attenuated parasite display immunity to multiple malaria species for over 100 days. These data indicate that vaccination with chemically attenuated parasites provides and suggest that such vaccines could be used to target human malaria species.

More information: Cross-species malaria immunity induced by chemically attenuated parasites, J Clin Invest. doi:10.1172/JCI66634

add to favorites email to friend print save as pdf

Related Stories

Malaria's severity reset by mosquito

May 30, 2013

(Medical Xpress)—For the first time, researchers have proven that the way in which malaria is transmitted to the host affects how severe the resulting infection will be.

Improving human immunity to malaria

Aug 01, 2012

The deadliest form of malaria is caused the protozoan Plasmodium falciparum. During its life-cycle in human blood, the parasite P. falciparum expresses unique proteins on the surface on infected blood cells. ...

Recommended for you

New technology allows hair to reflect almost any color

Jul 25, 2014

What if you could alter your hair to reflect any color in the spectrum? What if you could use a flatiron to press a pattern into your new hair color? Those are possibilities suggested by researchers from ...

User comments