Researchers explore genetic links between nicotine, cancer using 'next-generation sequencing'

July 29, 2013

Researchers at the Virginia Bioinformatics Institute have taken a closer look at the role that nicotine plays in cancer, finding new consequences of nicotine stress on breast tissue and insight into the influence of nicotine on normal cells.

Nicotine is the addictive chemical found in cigarettes, but researchers believe that it could have more influence than previously realized on the underlying genetics of cancer, according to a recently published study in the journal PLOS One. Tobacco smoke contains many chemicals, including nicotine, but nicotine stands out because of its widely accepted connection to cancer, especially lung cancer.

Using next-generation sequencing techniques, Jasmin Bavarva, a research geneticist and lead author of the study, showed more thoroughly how nicotine causes healthy cells to become cancerous and revealed new participation from previously unstudied genes.

Next-generation sequencing allows researchers to see a broad range of gene interactions in ways that supersede standard techniques, such as microarrays.

"The all-inclusive approach of next-generation sequencing is a game-changer, as it allows us to find previously unknown genetic links," Bavarva said.

Knowing how the genes interact can help researchers understand the complex nature of cancer and find treatments, the researchers said.

"The changes seen in cells after exposure to nicotine must make us now realize that nicotine is not just an addicting chemical, but it also is a gene-expression modulator, which may play a direct role in cancer development. We may need to rethink how we use it to treat ," said Harold R. Garner, a professor of , computer science, and basic science affiliated with the College of Science, the College of Engineering, and the Virginia Tech Carilion School of Medicine, who led the research.

Explore further: Reining in nicotine use: Midbrain habenula region plays key role in nicotine dependence

More information: PLoS ONE 8(6): e67252. doi:10.1371/journal.pone.0067252

Related Stories

Helping ex-smokers resist the urge

October 22, 2012

A new inhibitor helps previously nicotine-addicted rats stay on the wagon, according to a study published on October 22nd in the Journal of Experimental Medicine.

New molecularly imprinted nicotine receptors

July 9, 2013

Researchers from the National Environmental Engineering Research Institute in Nehru Marg, India have added another piece to the puzzle of how to synthetize an artificial nicotine receptor. Nicotine - the infamous principal ...

Recommended for you

New findings offer hope for diabetic wound healing

November 23, 2015

University of Notre Dame researchers have discovered a compound that accelerates diabetic wound healing, which may open the door to new treatment strategies. Non-healing chronic wounds are a major complication of diabetes, ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.