High H. pylori cure rate for nonbismuth quadruple Tx

High <i>H. pylori</i> cure rate for nonbismuth quadruple tx
Optimized nonbismuth quadruple regimens, either hybrid or concomitant, have a cure rate of more than 90 percent for Helicobacter pylori infections, according to a study published in the July issue of Gastroenterology.

(HealthDay)—Optimized nonbismuth quadruple regimens, either hybrid or concomitant, have a cure rate of more than 90 percent for Helicobacter pylori (H. pylori) infections, according to a study published in the July issue of Gastroenterology.

Javier Molina-Infante, M.D., from the Hospital San Pedro de Alcantara in Caceres, Spain, and colleagues compared the efficacy of two optimized nonbismuth quadruple regimens among 343 consecutive individuals with H. pylori infection. Participants were randomized to receive hybrid therapy ( and , twice daily for 14 days, plus clarithromycin and nitroimidazole twice daily for final seven days) or concomitant therapy (same drugs taken concurrently, twice daily for 14 days).

The researchers found that rates of eradication for hybrid and concomitant therapies were 92 and 96.1 percent, respectively (P = 0.07), in per-protocol analysis. The rates were 90 and 91.7 percent, respectively (P = 0.35) in intention-to-treat analysis. Full compliance was high at 95.5 percent. H. pylori strains that were resistant to clarithromycin, , and both drugs were seen in 23.5, 33, and 8.8 percent of patients, respectively. Nearly half (51.5 percent) of patients reported mild side effects. The only significant predictor of eradication was compliance greater than 80 percent (odds ratio, 12.5). Compliance was significantly higher for hybrid therapy versus concomitant therapy (98.8 versus 95.2 percent; P = 0.05).

"Optimized nonbismuth quadruple hybrid and concomitant therapies cured more than 90 percent of patients with H. pylori infections in areas of high and metronidazole resistance," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Ebola in mind, US colleges screen some students

3 hours ago

University students from West Africa may be subject to extra health checks when they arrive to study in the United States as administrators try to insulate their campuses from the worst Ebola outbreak in ...

WHO: More Ebola cases in past week than any other

4 hours ago

The past week has seen the highest increase of Ebola cases since the outbreak in West Africa began, the World Health Organization said Friday, offering more evidence that the crisis is worsening.

Guidelines presented for diagnosing focal liver lesions

19 hours ago

(HealthDay)—Focal liver lesions (FLLs) are mostly benign, and can be diagnosed based on knowledge of their presentation, associated clinical and laboratory features, and natural history, according to clinical ...

User comments