High H. pylori cure rate for nonbismuth quadruple Tx

High <i>H. pylori</i> cure rate for nonbismuth quadruple tx
Optimized nonbismuth quadruple regimens, either hybrid or concomitant, have a cure rate of more than 90 percent for Helicobacter pylori infections, according to a study published in the July issue of Gastroenterology.

(HealthDay)—Optimized nonbismuth quadruple regimens, either hybrid or concomitant, have a cure rate of more than 90 percent for Helicobacter pylori (H. pylori) infections, according to a study published in the July issue of Gastroenterology.

Javier Molina-Infante, M.D., from the Hospital San Pedro de Alcantara in Caceres, Spain, and colleagues compared the efficacy of two optimized nonbismuth quadruple regimens among 343 consecutive individuals with H. pylori infection. Participants were randomized to receive hybrid therapy ( and , twice daily for 14 days, plus clarithromycin and nitroimidazole twice daily for final seven days) or concomitant therapy (same drugs taken concurrently, twice daily for 14 days).

The researchers found that rates of eradication for hybrid and concomitant therapies were 92 and 96.1 percent, respectively (P = 0.07), in per-protocol analysis. The rates were 90 and 91.7 percent, respectively (P = 0.35) in intention-to-treat analysis. Full compliance was high at 95.5 percent. H. pylori strains that were resistant to clarithromycin, , and both drugs were seen in 23.5, 33, and 8.8 percent of patients, respectively. Nearly half (51.5 percent) of patients reported mild side effects. The only significant predictor of eradication was compliance greater than 80 percent (odds ratio, 12.5). Compliance was significantly higher for hybrid therapy versus concomitant therapy (98.8 versus 95.2 percent; P = 0.05).

"Optimized nonbismuth quadruple hybrid and concomitant therapies cured more than 90 percent of patients with H. pylori infections in areas of high and metronidazole resistance," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Reducing kidney injury using a quality improvement method

3 hours ago

Using quality improvement measures in eight of the 10 hospitals in the Northern New England Cardiovascular Disease Study Group, researchers have found a way to reduce kidney injury in patients undergoing a procedure with ...

App for headache sufferers shows success

15 hours ago

A unique app that helps headache sufferers to record the severity and regularity of their pain is being used as part of a Griffith research study.

West African airline suspends flights amid Ebola (Update)

21 hours ago

(AP)—Police officers deployed to Liberia's international airport to ensure passengers are screened for Ebola symptoms as a major regional airline announced Tuesday it was suspending flights to the cities hardest hit by ...

User comments