Most people with moderate kidney disease have medication-resistant hypertension

More than 50% of individuals with moderate kidney disease have hypertension that is resistant to medications, and those who are black or have a larger waist circumference, diabetes, or a history of heart attacks or strokes are at highest risk, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN). The findings could help identify kidney disease patients who need more intensive monitoring and treatments for hypertension.

Approximately 60 million people globally have (CKD). Hypertension is common among these patients and is linked with poor health outcomes in the future. Resistant hypertension, which is particularly serious, refers to blood pressure that requires four or more classes of antihypertensive medications to achieve . Rikki Tanner, MPH, Paul Muntner, PhD (University of Alabama at Birmingham School of Public Health) and their colleagues looked for a link between kidney function and resistant hypertension among 10,700 participants who were treated for hypertension in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study.

Among the major findings:

  • There was a strong, graded association between worse and the presence of resistant hypertension.
  • More than 50% of individuals with moderate CKD had resistant hypertension.
  • Among people with CKD, blacks and those with a larger waist circumference, diabetes, and a history of heart attacks or strokes were more likely to have resistant hypertension.

"These data indicate that resistant hypertension is a common condition among individuals with kidney disease, suggesting the need for greater awareness of this comorbidity among clinicians," said Tanner. "The identification of individuals at high risk of developing resistant hypertension who may benefit from intensive and early therapeutic interventions—such as treatment for secondary hypertension, referral to a hypertension specialist, and cessation of medications that increase blood pressure—should be a high priority," she added.

More information: doi: 10.2215/CJN.00550113

add to favorites email to friend print save as pdf

Related Stories

Relation of poor sleep quality to resistant hypertension

Sep 21, 2012

For people who already have high blood pressure, insomnia can have serious consequences, according to a new study presented at the American Heart Association's High Blood Pressure Research 2012 Scientific Sessions.

New guidelines for treating resistant hypertension

Jun 06, 2008

Resistant hypertension, blood pressure that remains above goal despite taking three antihypertensive medications or high blood pressure that is controlled but requires four or more medications to do so, may benefit from specialized ...

Recommended for you

Routines most vital in avoiding Ebola infection: WHO

12 hours ago

Meticulously following stringent routines when putting on and removing protective equipment is more important than the kind of gear health care workers use to ward off Ebola infection, the World Health Organization said Friday.

A look at latest Ebola developments

13 hours ago

No African countries are on the United Nations list of contributors to fight Ebola. With few exceptions, African governments and institutions are offering only marginal support as the continent faces its ...

Liberia opens one of largest Ebola treatment centers

13 hours ago

Remembering those who have died in the world's deadliest Ebola outbreak, Liberia's president opened one of the country's largest Ebola treatment centers in Monrovia on Friday amid hopes that the disease is ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.