Most people with moderate kidney disease have medication-resistant hypertension

More than 50% of individuals with moderate kidney disease have hypertension that is resistant to medications, and those who are black or have a larger waist circumference, diabetes, or a history of heart attacks or strokes are at highest risk, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN). The findings could help identify kidney disease patients who need more intensive monitoring and treatments for hypertension.

Approximately 60 million people globally have (CKD). Hypertension is common among these patients and is linked with poor health outcomes in the future. Resistant hypertension, which is particularly serious, refers to blood pressure that requires four or more classes of antihypertensive medications to achieve . Rikki Tanner, MPH, Paul Muntner, PhD (University of Alabama at Birmingham School of Public Health) and their colleagues looked for a link between kidney function and resistant hypertension among 10,700 participants who were treated for hypertension in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study.

Among the major findings:

  • There was a strong, graded association between worse and the presence of resistant hypertension.
  • More than 50% of individuals with moderate CKD had resistant hypertension.
  • Among people with CKD, blacks and those with a larger waist circumference, diabetes, and a history of heart attacks or strokes were more likely to have resistant hypertension.

"These data indicate that resistant hypertension is a common condition among individuals with kidney disease, suggesting the need for greater awareness of this comorbidity among clinicians," said Tanner. "The identification of individuals at high risk of developing resistant hypertension who may benefit from intensive and early therapeutic interventions—such as treatment for secondary hypertension, referral to a hypertension specialist, and cessation of medications that increase blood pressure—should be a high priority," she added.

More information: doi: 10.2215/CJN.00550113

add to favorites email to friend print save as pdf

Related Stories

Relation of poor sleep quality to resistant hypertension

Sep 21, 2012

For people who already have high blood pressure, insomnia can have serious consequences, according to a new study presented at the American Heart Association's High Blood Pressure Research 2012 Scientific Sessions.

New guidelines for treating resistant hypertension

Jun 06, 2008

Resistant hypertension, blood pressure that remains above goal despite taking three antihypertensive medications or high blood pressure that is controlled but requires four or more medications to do so, may benefit from specialized ...

Recommended for you

Ebola reveals shortcomings of African solidarity

5 hours ago

As Africa's leaders meet in Ethiopia to discuss the Ebola crisis, expectations of firm action will be tempered by criticism over the continent's poor record in the early stages of the epidemic.

Second bird flu case confirmed in Canada

21 hours ago

The husband of a Canadian who was diagnosed earlier this week with bird flu after returning from a trip to China has also tested positive for the virus, health officials said Friday.

What exactly is coronavirus?

Jan 30, 2015

The conflicts in Syria and Iraq are straining public health systems and public health efforts meant to prevent and detect the spread of infectious diseases. This is generating a "perfect storm" of conditions for outbreaks. Among the infections raising concern is Middle East Respiratory Syndrome, caused by a type of coronavirus, which emerged in 2012. ...

Scientists find Ebola virus is mutating

Jan 30, 2015

(Medical Xpress)—Researchers working at Institut Pasteur in France have found that the Ebola virus is mutating "a lot" causing concern in the African countries where the virus has killed over eight thous ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.