Novel bacterium linked to cord colitis syndrome

Novel bacterium linked to cord colitis syndrome
A novel bacterium is associated with cord colitis syndrome, a complication of umbilical-cord hematopoietic stem-cell transplantation, according to a study published in the Aug. 8 issue of the New England Journal of Medicine.

(HealthDay)—A novel bacterium is associated with cord colitis syndrome, a complication of umbilical-cord hematopoietic stem-cell transplantation, according to a study published in the Aug. 8 issue of the New England Journal of Medicine.

To examine whether cord colitis syndrome has an infectious origin, Ami S. Bhatt, M.D., Ph.D., from the Dana-Farber Cancer Institute in Boston, and colleagues performed shotgun DNA sequencing on four endoscopic colon-biopsy specimens from two patients with cord colitis. Human and known microbial sequences were removed and the residual sequences were assembled into a bacterial draft genome.

The researchers found 2.5 million sequencing reads that did not match known organisms and were then assembled into a 7.65-Mb draft genome. The genome was highly homologous to bacteria in the bradyrhizobium genus and named Bradyrhizobium enterica. DNA from B. enterica was present in biopsies from three additional patients with cord colitis but absent from samples from healthy controls and patients with or graft-versus-host disease.

"Although we have not shown that B. enterica is the cause of cord colitis, we have demonstrated the usefulness of sequencing-based technologies for the unbiased identification of previously undiscovered candidate ," Bhatt and colleagues conclude.

More information: Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Fecal transplant studied for kids with bowel disease

Apr 17, 2013

(HealthDay)—Fecal transplantation—an innovative enema treatment—may help reduce or eliminate symptoms of ulcerative colitis in most children and young adults, according to a small study.

Possible link between bacterium, colon cancer found

Oct 17, 2011

For the first time, a specific microorganism has been found to be associated with human colorectal cancer. In two studies published online today in Genome Research, independent research teams have identified Fusobacterium in col ...

Immune sensors suppress colitis-associated cancer

Apr 12, 2010

Particular components of inflammasomes -- protein complexes needed for generating immune responses to pathogens and cellular damage—lessen the severity of colitis and colitis-associated colon cancer in mice, according to ...

Recommended for you

Sierra Leone reaches final day of Ebola lockdown

2 hours ago

Frustrated residents complained of food shortages in some neighborhoods of Sierra Leone's capital on Sunday as the country reached the third and final day of a sweeping, unprecedented lockdown designed to ...

Sierra Leone faces criticism over Ebola shutdown

Sep 20, 2014

Sierra Leone began the second day of a 72-hour nationwide shutdown aimed at containing the spread of the deadly Ebola virus on Saturday amid criticism that the action was a poorly planned publicity stunt.

Presence of peers ups health workers' hand hygiene

Sep 19, 2014

(HealthDay)—The presence of other health care workers improves hand hygiene adherence, according to a study published in the October issue of Infection Control and Hospital Epidemiology.

Sierra Leone streets deserted as shutdown begins

Sep 19, 2014

Sierra Leone's normally chaotic capital resembled a ghost town on Friday as residents were confined to their homes for the start of a three-day lockdown aimed at halting the deadly Ebola epidemic.

User comments