Novel bacterium linked to cord colitis syndrome

Novel bacterium linked to cord colitis syndrome
A novel bacterium is associated with cord colitis syndrome, a complication of umbilical-cord hematopoietic stem-cell transplantation, according to a study published in the Aug. 8 issue of the New England Journal of Medicine.

(HealthDay)—A novel bacterium is associated with cord colitis syndrome, a complication of umbilical-cord hematopoietic stem-cell transplantation, according to a study published in the Aug. 8 issue of the New England Journal of Medicine.

To examine whether cord colitis syndrome has an infectious origin, Ami S. Bhatt, M.D., Ph.D., from the Dana-Farber Cancer Institute in Boston, and colleagues performed shotgun DNA sequencing on four endoscopic colon-biopsy specimens from two patients with cord colitis. Human and known microbial sequences were removed and the residual sequences were assembled into a bacterial draft genome.

The researchers found 2.5 million sequencing reads that did not match known organisms and were then assembled into a 7.65-Mb draft genome. The genome was highly homologous to bacteria in the bradyrhizobium genus and named Bradyrhizobium enterica. DNA from B. enterica was present in biopsies from three additional patients with cord colitis but absent from samples from healthy controls and patients with or graft-versus-host disease.

"Although we have not shown that B. enterica is the cause of cord colitis, we have demonstrated the usefulness of sequencing-based technologies for the unbiased identification of previously undiscovered candidate ," Bhatt and colleagues conclude.

More information: Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Fecal transplant studied for kids with bowel disease

Apr 17, 2013

(HealthDay)—Fecal transplantation—an innovative enema treatment—may help reduce or eliminate symptoms of ulcerative colitis in most children and young adults, according to a small study.

Possible link between bacterium, colon cancer found

Oct 17, 2011

For the first time, a specific microorganism has been found to be associated with human colorectal cancer. In two studies published online today in Genome Research, independent research teams have identified Fusobacterium in col ...

Immune sensors suppress colitis-associated cancer

Apr 12, 2010

Particular components of inflammasomes -- protein complexes needed for generating immune responses to pathogens and cellular damage—lessen the severity of colitis and colitis-associated colon cancer in mice, according to ...

Recommended for you

Restrictions lifted at British bird flu farm

14 hours ago

Britain on Sunday lifted all restrictions at a duck farm in northern England after last month's outbreak of H5N8 bird flu, the same strain seen in recent cases across Europe.

Recorded Ebola deaths top 7,000

Dec 20, 2014

The worst Ebola outbreak on record has now killed more than 7,000 people, with many of the latest deaths reported in Sierra Leone, the World Health Organization said as United Nations Secretary-General Ban ...

Liberia holds Senate vote amid Ebola fears (Update)

Dec 20, 2014

Health workers manned polling stations across Liberia on Saturday as voters cast their ballots in a twice-delayed Senate election that has been criticized for its potential to spread the deadly Ebola disease.

Evidence-based recs issued for systemic care in psoriasis

Dec 19, 2014

(HealthDay)—For appropriately selected patients with psoriasis, combining biologics with other systemic treatments, including phototherapy, oral medications, or other biologic, may result in greater efficacy ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.