Who benefits from vitamin D?

Studying the expression of genes that are dependent on vitamin D makes it possible to identify individuals who will benefit from vitamin D supplementation, shows a University of Eastern Finland study published recently in PLoS One.

Population-based studies have shown that vitamin D deficiency may increase the risk for chronic diseases and weaken the body's immune system. In the present study carried out at the University of Eastern Finland, Kuopio, the were given a daily dose of either 40 or 80 micrograms of vitamin D, or a placebo, over a course of 5 months during Finnish winter. The results showed that the expression of vitamin D dependent genes in adipose tissue and monocytes, i.e. , correlated only in half of the study participants with their vitamin D concentrations in the blood.

The researchers concluded that persons whose expression of the CD14 and thrombomodulin genes was not altered as a result of vitamin D supplementation already had a sufficiently high serum vitamin D concentration or their utilization of vitamin D was disturbed, which calls for further study. The researchers believe that studying the expression of vitamin D dependent genes in tissues is a novel way to identify individuals who might benefit from long-term vitamin D supplementation. This observation is further supported by the fact that studying alterations in the expression of genes also made it possible to identify persons whose levels of , an inflammation marker, were reduced as their serum vitamin D levels increased.

More information: Carlberg C, et al. (2013) Primary Vitamin D Target Genes Allow a Categorization of Possible Benefits of Vitamin D3 Supplementation. PLoS ONE 8(7): e71042. DOI: 10.1371/journal.pone.0071042

Related Stories

Low vitamin D levels a risk factor for pneumonia

date Apr 30, 2013

A University of Eastern Finland study showed that low serum vitamin D levels are a risk factor for pneumonia. The risk of contracting pneumonia was more than 2.5 times greater in subjects with the lowest vitamin D levels ...

Recommended for you

UK doctors unlikely to be able to repay student loans

date 2 hours ago

UK doctors are unlikely to be able to repay their student loans over the course of their working lives, amassing debts of more than £80,000 by the time they graduate, in some cases, finds research published in the online ...

Reducing global tobacco use

date 9 hours ago

Although global efforts to cut tobacco use have had some success, more can be done to reduce the number of deaths from smoking, according to a commentary published in CMAJ (Canadian Medical Association Journal). ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.