Early-life probiotics reduce allergies, not asthma

August 20, 2013
Early-life probiotics reduce allergies, not asthma
Probiotic exposure in early life may reduce total immunoglobulin E level and protect against atopic sensitization, but does not seem to protect against asthma/wheezing, according to a meta-analysis published online Aug. 19 in Pediatrics.

(HealthDay)—Probiotic exposure in early life may reduce total immunoglobulin E level (IgE) and protect against atopic sensitization, but does not seem to protect against asthma/wheezing, according to a meta-analysis published online Aug. 19 in Pediatrics.

In an effort to assess the effects of probiotic supplementation on atopic sensitization and asthma/wheeze prevention in children, Nancy Elazab, M.D., from the University of Miami, and colleagues used a random-effects model to calculate pooled risk estimates. The effect of factors influencing probiotics efficacy was examined with meta-regression.

The researchers found that probiotics were effective in reducing total IgE (P = 0.044), and the reduction in IgE was more pronounced with longer follow-up. Probiotics significantly reduced the risk of atopic sensitization both when administered prenatally (relative risk, 0.88; P = 0.035 for positive result on the skin prick test and/or elevated specific IgE to common ) and when administered postnatally (relative risk, 0.86; P = 0.027 for positive result on skin prick test). There was a significantly increased risk of atopic sensitization with administration of Lactobacillus acidophilus, compared with other (P = 0.002). Asthma/wheeze were not significantly reduced with probiotics (relative risk, 0.96; 95 percent confidence interval, 0.85 to 1.07).

"Prenatal and/or early-life probiotic administration reduces the risk of atopic and decreases the total IgE level in children but may not reduce the risk of asthma/wheeze," the authors write.

Explore further: AAAAI: Prevalence of asthma, hay fever lower among Amish

More information: Abstract
Full Text

Related Stories

AAAAI: Prevalence of asthma, hay fever lower among Amish

March 6, 2012

(HealthDay) -- The prevalence of asthma, hay fever, and allergic sensitization is significantly lower among the Amish population than among Swiss children, according to a study presented at the annual meeting of the American ...

Perceived stress linked to asthma, atopic disorders

September 21, 2012

(HealthDay)—Perceived stress correlates with an increased risk of adult-onset asthma, allergic rhinitis, and atopic dermatitis as well as asthma medication use, according to a study published online Sept. 3 in Allergy.

Probiotics do not prevent relapse in Crohn's disease patients

August 14, 2013

Despite previous data showing beneficial effects, the probiotic Saccharomuces boulardii (S. boulardii) does not prevent clinical relapse in patients with Crohn's disease, according to a new study in Clinical Gastroenterology ...

Recommended for you

Youth dance classes score low in physical activity

May 18, 2015

For parents who send their kids to dance classes to get some exercise, a new study from researchers at University of California, San Diego School of Medicine suggests most youth dance classes provide only limited amounts ...

Roller coaster rides trigger pediatric stroke

December 11, 2014

Riding a couple roller coasters at an amusement park appears to have triggered an unusual stroke in a 4-year-old boy, according to a report in the journal Pediatric Neurology.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.