First-trimester biomarker may help identify early GDM risk

August 9, 2013
First-trimester biomarker may help identify early GDM risk
Glycosylated fibronectin may be able to identify pregnant women during the first trimester at risk for developing gestational diabetes mellitus, according to a study published online Aug. 5 in Obstetrics & Gynecology.

(HealthDay)—Glycosylated fibronectin may be able to identify pregnant women during the first trimester at risk for developing gestational diabetes mellitus (GDM), according to a study published online Aug. 5 in Obstetrics & Gynecology.

Juha P. Rasanen, M.D., Ph.D., from the Oregon Health and Science University in Portland, and colleagues measured serum concentrations of glycosylated (Sambucus nigra lectin-reactive) fibronectin, adiponectin, sex hormone-binding globulin, placental lactogen, and high-sensitivity C-reactive protein (CRP) in 90 pregnant women (who subsequently developed GDM) at 5 to 13 weeks of gestation and in 92 control participants.

The researchers observed a significant association between GDM and serum concentrations of glycosylated fibronectin, adiponectin, high-sensitivity CRP, and placental lactogen. Glycosylated fibronectin remained independently associated with GDM after adjusting for maternal factors and other markers. Above a threshold of 120 mg/L, glycosylated fibronectin levels correctly identified 57 GDM case group participants, with a positive predictive value of 63 percent and a negative predictive value of 95 percent, at a population prevalence of 12 percent.

"First-trimester glycosylated is a potential pregnancy-specific biomarker for early identification of women at risk for GDM," the authors write.

Several authors disclosed financial ties to DiabetOmics, which funded the study.

Explore further: High fruit consumption not linked to gestational diabetes

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

High fruit consumption not linked to gestational diabetes

March 29, 2012

(HealthDay) -- Higher consumption of whole fruits prior to pregnancy is not associated with increased risk of gestational diabetes mellitus (GDM), and the association between fruit juice consumption and GDM appears to be ...

BMI thresholds for gestational diabetes differ by race

June 1, 2012

(HealthDay) -- There is considerable racial/ethnic variation in the prevalence of gestational diabetes mellitus (GDM) by body mass index (BMI), according to a study published online May 22 in Diabetes Care.

Gestational diabetes ups costs of maternity care by one-third

January 22, 2013

(HealthDay)—Women with gestational diabetes mellitus (GDM) are significantly more likely to receive an emergency cesarean section, have their infant admitted to a neonatal care unit, and incur significantly higher maternity ...

Low adiponectin in first trimester linked to GDM

February 1, 2013

(HealthDay)—Low adiponectin levels during the first trimester of pregnancy correlate with a higher level of insulin resistance and an increased risk of developing gestational diabetes mellitus (GDM), according to research ...

Rates of gestational diabetes mellitus vary by state

June 18, 2013

(HealthDay)—Obesity, age, race/ethnicity, hospital characteristics, and insurance type may contribute to the variability in rates of gestational diabetes mellitus (GDM) between states, according to research published in ...

Recommended for you

Does mom's cellphone startle the fetus?

May 6, 2015

(HealthDay)—The sounds emitted by cellphones carried by pregnant women may rattle the sleep-and-wake cycles of their fetuses, new research suggests.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.