First-trimester biomarker may help identify early GDM risk

First-trimester biomarker may help identify early GDM risk
Glycosylated fibronectin may be able to identify pregnant women during the first trimester at risk for developing gestational diabetes mellitus, according to a study published online Aug. 5 in Obstetrics & Gynecology.

(HealthDay)—Glycosylated fibronectin may be able to identify pregnant women during the first trimester at risk for developing gestational diabetes mellitus (GDM), according to a study published online Aug. 5 in Obstetrics & Gynecology.

Juha P. Rasanen, M.D., Ph.D., from the Oregon Health and Science University in Portland, and colleagues measured serum concentrations of glycosylated (Sambucus nigra lectin-reactive) fibronectin, adiponectin, sex hormone-binding globulin, placental lactogen, and high-sensitivity C-reactive protein (CRP) in 90 pregnant women (who subsequently developed GDM) at 5 to 13 weeks of gestation and in 92 control participants.

The researchers observed a significant association between GDM and serum concentrations of glycosylated fibronectin, adiponectin, high-sensitivity CRP, and placental lactogen. Glycosylated fibronectin remained independently associated with GDM after adjusting for maternal factors and other markers. Above a threshold of 120 mg/L, glycosylated fibronectin levels correctly identified 57 GDM case group participants, with a positive predictive value of 63 percent and a negative predictive value of 95 percent, at a population prevalence of 12 percent.

"First-trimester glycosylated is a potential pregnancy-specific biomarker for early identification of women at risk for GDM," the authors write.

Several authors disclosed financial ties to DiabetOmics, which funded the study.

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Low adiponectin in first trimester linked to GDM

date Feb 01, 2013

(HealthDay)—Low adiponectin levels during the first trimester of pregnancy correlate with a higher level of insulin resistance and an increased risk of developing gestational diabetes mellitus (GDM), according ...

Rates of gestational diabetes mellitus vary by state

date Jun 18, 2013

(HealthDay)—Obesity, age, race/ethnicity, hospital characteristics, and insurance type may contribute to the variability in rates of gestational diabetes mellitus (GDM) between states, according to research ...

Recommended for you

Self-hypnosis training doesn't cut epidural use

date May 26, 2015

(HealthDay)—Self-hypnosis training does not reduce women's epidural use during childbirth, according to a study published online May 11 in BJOG: An International Journal of Obstetrics and Gynaecology.

ACOG urges expedited partner therapy for some STIs

date May 25, 2015

(HealthDay)—For patients with sexually transmitted infections (STIs), such as gonorrhea and chlamydia, whose partners are unable or unwilling to seek care, expedited partner therapy can be used to prevent ...

German woman, 65, gives birth to quadruplets

date May 23, 2015

A 65-year-old teacher from Berlin has given birth to quadruplets after a pregnancy that was widely criticized by medical professionals because of her age, RTL television said Saturday.

More evidence C-sections riskier for moms

date May 20, 2015

(HealthDay)—Women who deliver their first baby by cesarean section are more likely to need blood transfusions and be admitted to intensive care units than women who opt for a vaginal delivery, U.S. health ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.