First-trimester biomarker may help identify early GDM risk

First-trimester biomarker may help identify early GDM risk
Glycosylated fibronectin may be able to identify pregnant women during the first trimester at risk for developing gestational diabetes mellitus, according to a study published online Aug. 5 in Obstetrics & Gynecology.

(HealthDay)—Glycosylated fibronectin may be able to identify pregnant women during the first trimester at risk for developing gestational diabetes mellitus (GDM), according to a study published online Aug. 5 in Obstetrics & Gynecology.

Juha P. Rasanen, M.D., Ph.D., from the Oregon Health and Science University in Portland, and colleagues measured serum concentrations of glycosylated (Sambucus nigra lectin-reactive) fibronectin, adiponectin, sex hormone-binding globulin, placental lactogen, and high-sensitivity C-reactive protein (CRP) in 90 pregnant women (who subsequently developed GDM) at 5 to 13 weeks of gestation and in 92 control participants.

The researchers observed a significant association between GDM and serum concentrations of glycosylated fibronectin, adiponectin, high-sensitivity CRP, and placental lactogen. Glycosylated fibronectin remained independently associated with GDM after adjusting for maternal factors and other markers. Above a threshold of 120 mg/L, glycosylated fibronectin levels correctly identified 57 GDM case group participants, with a positive predictive value of 63 percent and a negative predictive value of 95 percent, at a population prevalence of 12 percent.

"First-trimester glycosylated is a potential pregnancy-specific biomarker for early identification of women at risk for GDM," the authors write.

Several authors disclosed financial ties to DiabetOmics, which funded the study.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Low adiponectin in first trimester linked to GDM

Feb 01, 2013

(HealthDay)—Low adiponectin levels during the first trimester of pregnancy correlate with a higher level of insulin resistance and an increased risk of developing gestational diabetes mellitus (GDM), according ...

Rates of gestational diabetes mellitus vary by state

Jun 18, 2013

(HealthDay)—Obesity, age, race/ethnicity, hospital characteristics, and insurance type may contribute to the variability in rates of gestational diabetes mellitus (GDM) between states, according to research ...

Recommended for you

Cinnamon may improve menstrual cyclicity in PCOS

4 hours ago

(HealthDay)—For women with polycystic ovary syndrome (PCOS), cinnamon supplements may improve menstrual cyclicity, according to a study published in the November issue of the American Journal of Obstetrics & ...

Vitamin D may not prevent return of vaginosis after all

Oct 29, 2014

(HealthDay)—A new study suggests that high doses of vitamin D may not help prevent the return of bacterial vaginosis (BV). The research was published in the November issue of the American Journal of Obstetrics and Gynecology.

Eating disorders linked to adverse perinatal outcomes

Oct 22, 2014

(HealthDay)—Maternal eating disorders are associated with adverse pregnancy, obstetric, and perinatal health outcomes, according to a study published in the October issue of the American Journal of Obstetrics & ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.