High pain sensitivity linked to dry eye disease symptoms

High pain sensitivity linked to dry eye disease symptoms
Pain sensitivity and pain tolerance are associated with symptoms of dry eye disease, according to a study published online Aug. 1 in JAMA Ophthalmology.

(HealthDay)—Pain sensitivity and pain tolerance are associated with symptoms of dry eye disease (DED), according to a study published online Aug. 1 in JAMA Ophthalmology.

Jelle Vehof, Ph.D., from King's College London, and colleagues conducted a cross-sectional study involving 1,622 female twin volunteers, aged 20 to 83 years, to explore whether pain sensitivity plays a role in patients' experience of DED symptoms. The Ocular Surface Disease Index (OSDI) questionnaire was completed by a subset of 689 women. Quantitative sensory testing was used to assess pain sensitivity and pain tolerance.

The researchers found that 27 percent of the participants were categorized as having DED. Compared to those without DED, women with DED showed a significantly lower heat (HPT) and heat pain suprathreshold (HPST). The presence of pain symptoms on the OSDI correlated significantly with the HPT and HPST. DED pain symptoms were almost twice as common for participants with an HPT below the median versus those with an HPT above the median.

"High and low are associated with symptoms of DED, adding to previous associations of the severity of tear insufficiency, cell damage, and psychological factors," the authors write. "Management of DED symptoms is complex, and physicians need to consider the holistic picture, rather than simply treating ocular signs."

The study was partially supported by Pfizer.

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Study looks at pain processing abnormalities in knee OA

date Sep 17, 2012

(HealthDay)—For patients with knee osteoarthritis (K-OA), the lack of correlation between clinical pain and radiographic evidence of disease severity may be due to central sensitization, according to a ...

Placebo effects of different therapies not identical

date Jul 31, 2013

Not all placebos are equal, and patients who respond to one placebo don't always respond to others, according to research published July 31 in the open access journal PLOS ONE by Jian Kong from Massachusetts General Hospit ...

Weather conditions do not affect fibromyalgia pain or fatigue

date Jun 04, 2013

Dutch researchers report that weather conditions including temperature, sunshine, and precipitation have no impact on fibromyalgia symptoms in female patients. Results published in Arthritis Care & Research, a journal of the ...

Recommended for you

Lowering risk of a major eye disease

date May 20, 2015

Age-related macular degeneration (AMD), a chronic, progressive disease, is a leading cause of blindness among people aged 65 and older. Vision impairment due to advanced AMD significantly reduces quality ...

Age-related macular degeneration, mortality linked

date May 12, 2015

(HealthDay)—Age-related macular degeneration (AMD) is a predictor of poor survival, especially among women aged 80 years and older, according to a study published online May 4 in the Journal of the American Ge ...

Short-sightedness becoming more common across Europe

date May 11, 2015

Myopia or short-sightedness is becoming more common across Europe, according to a new study led by King's College London. The meta-analysis of findings from 15 studies by the European Eye Epidemiology Consortium ...

Smart microchips may optimise human vision

date May 11, 2015

To date, chip-based retinal implants have only permitted a rudimentary restoration of vision. However, modifying the electrical signals emitted by the implants could change that. This is the conclusion of ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.