Multimodal analgesia lessens post-op morphine needs

Multimodal analgesia lessens post-op morphine needs
A multimodal analgesia combination appears to be safe and effective for pain relief after lumbar decompressive laminectomy, according to a study published in the August issue of the Journal of Spinal Disorders & Techniques.

(HealthDay)—A multimodal analgesia combination appears to be safe and effective for pain relief after lumbar decompressive laminectomy, according to a study published in the August issue of the Journal of Spinal Disorders & Techniques.

Ryan Michael Garcia, M.D., from the Case Western Reserve University in Cleveland, and colleagues randomly assigned 22 undergoing a primary multilevel lumbar decompression procedure to receive either intravenous morphine alone or a multimodal (celecoxib, pregabalin, extended release oxycodone) analgesic regimen. All patients, postoperatively, could receive intravenous morphine on an as-needed basis. A visual analog scale was used to assess postoperative pain levels which were documented at zero, four, eight, 12, 16, 24, and 36 hours.

The researchers observed no significant differences in available patient demographics, intraoperative blood loss, or postoperative hemovac drain output between study groups. Patients randomized to receive the multimodal analgesic regimen had lower total postoperative intravenous morphine requirements and lower morphine requirements at all predetermined time points. Patients receiving the multimodal analgesic regimen also had lower visual analog pain scores at all postoperative time points. Neither treatment group had major identifiable postoperative complications.

"Opioid and non-opioid analgesic combinations appear to be safe and effective after lumbar laminectomy," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Kidney-brain connection may help drive chronic kidney disease

13 hours ago

In addition to affecting blood pressure, high-salt intake can promote kidney function decline in patients with chronic kidney disease. A study appearing in an upcoming issue of the Journal of the American Society of Nephrology (J ...

Flu's grip on U.S. starting to weaken: CDC

13 hours ago

(HealthDay)—After a rough start to the flu season, the number of infections seems to have peaked and is even starting to decline in many parts of the nation, federal health officials reported Thursday.

Litchi fruit suspected in mystery illness in India

13 hours ago

A mysterious and sometimes fatal brain disease that has afflicted children in northeastern India for years could be linked to a toxic substance in litchi fruits, US researchers said Thursday.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.