Potential new drug for tuberculosis

August 5, 2013
Some strains of Mycobacterium tuberculosis, the bacterium that causes TB, have become resistant to most antibiotics — but researchers hope that a new synthetic molecule will be a more formidable weapon to fight them. Credit: CDC/ Dr. Ray Butler

A new drug capable of inhibiting growth of Mycobacterium tuberculosis is reported this week in Nature Medicine. The findings may improve therapeutic options for the treatment of drug resistant tuberculosis (TB).

One-third of the world's population is latently infected with M. tuberculosis and more than a million people die of TB each year. Multidrug- of M. tuberculosis are spreading, and therefore the need to develop new and improved drugs is urgent.

Kevin Pethe and colleagues screened a chemical library for inhibitors of M. tuberculosis growth in and identified imidazopyrimidine amides as potential candidates. The team then optimized these chemicals in order to generate the compound Q203. This compound, which showed efficacy in vitro and in a mouse model of established TB, targets part of the M. tuberculosis electron chain and therefore inhibits ATP synthesis—which is needed for cellular energy production.

The findings support the concept of targeting ATP synthesis to potentially eradicate both active and latent M. tuberculosis and provide a new candidate for clinical validation.

Explore further: Research reveals new drug target urgently needed for tuberculosis therapy

More information: Nature Medicine (2013) doi:10.1038/nm.3262

Related Stories

FDA approves first new tuberculosis in 40 years

December 31, 2012

The Food and Drug Administration says it has approved a Johnson & Johnson tuberculosis drug that is the first new medicine to fight the deadly infection in more than four decades.

Recommended for you

Researcher making headway in fighting migraines

December 5, 2016

A study by a UT Dallas researcher has revealed new information about a potential chemical causing pain hypersensitivity in migraines, which is the third most common disease in the world.

Zika in fetal brain tissue responds to a popular antibiotic

November 30, 2016

Working in the lab, UC San Francisco researchers have identified fetal brain tissue cells that are targeted by the Zika virus and determined that azithromycin, a common antibiotic regarded as safe for use during pregnancy, ...

Zika and glaucoma linked for first time in new study

November 30, 2016

A team of researchers in Brazil and at the Yale School of Public Health has published the first report demonstrating that the Zika virus can cause glaucoma in infants who were exposed to the virus during gestation.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.